Wnt信号通路在神经系统发育和神经系统疾病过程中的作用

摘要/Abstract

摘要： Wnt信号通路是广泛存在于多细胞真核生物中一条高度保守的信号通路,参与调控多种生命过程而且能够起到决定性的导向作用。脑外伤、脑卒中以及神经退行性疾病如阿尔茨海默病(AD)、帕金森病(PD)等仍是全世界面临的危害人类健康的重大疾病,呈现高致死率和高致残率。近几年,Wnt信号通路因其在神经发育和中枢神经系统(CNS)疾病中的重要作用而逐渐受到重视。全面而深入地阐明Wnt信号通路作用的分子机制可能为CNS疾病的预防和治疗提供新的思路和方法。本文概述了经典Wnt/β-catenin信号通路对神经细胞发育和死亡的调控作用及其与中枢神经系统疾病的关系。

关键词: Wnt信号通路, β-catenin, 糖原合成酶激酶-3β, 神经发育, 中枢神经系统疾病

Abstract: Wnt signaling pathway that widely exists in multicellular eukaryotes and plays an essential, decisive and directional role in regulation of a variety of life processes is one highly conservative signaling pathway. Traumatic brain injury, cerebral stroke and neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD) that have a high rate of fatality and disability, are still the important diseases threatening the health of human beings around the world. In recent years, Wnt signaling pathway has gradually drawn more and more attention from people for the critical role played in neural development and central nervous system (CNS) diseases. To clarify the molecular mechanisms of Wnt signaling pathway comprehensively and deeply will probably offer new ideas and methods to the prevention and treatment of CNS diseases. This article summarizes the important role in regulating cellular development and demise and the relationship of canonical Wnt/β-catenin signaling pathway with the neurological diseases.

Key words: Wnt/β-catenin, β-catenin, GSK-3β, Neural development, CNS diseases

中图分类号:

R966

刘美, 廖红. Wnt信号通路在神经系统发育和神经系统疾病过程中的作用[J]. 中国临床药理学与治疗学, 2013, 18(9): 1059-1064.

LIU Mei, LIAO Hong. The role of Wnt signaling pathway during central nervous system development and diseases[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(9): 1059-1064.

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