8-甲氧补骨脂素药理作用研究进展

摘要/Abstract

摘要： 8-甲氧补骨脂素(8-methoxypsoralen, 8-MOP) 主要存在于多种常见中草药如蛇床子、北沙参、白芷、枳实、羌活、芫荽等根茎或果实中,由于8-MOP结构简单、易与DNA发生相互作用,有较多的生物活性,目前已成为天然药物研究的热点。本文结合本实验室研究工作对近年8-MOP在抗微生物和抑制炎症反应、调节免疫功能、抗肿瘤作用、其他药理和毒副作用研究进展做一综述。

关键词: 8-甲氧补骨脂素, 药理作用, 抗肿瘤作用

Abstract: 8-methoxypsoralen (8-MOP) is widely distributed in the roots or fruits of Chinese medicinal herb, such as fructus cnidii, radix glehniae, angelica daharica, fructus aurantii immaturus, notopterygium and coriander. This paper overviews the advances and applications of 8-MOP in the antimicrobial and inhibition of inflammation, the regulation of immune function, anti-tumor effect, other pharmacological effects and toxicological effects basing on our work and crosslinking current researches at home and abroad.

Key words: 8-methoxypsoralen (8-MOP), pharmacological effect, antitumor effect

中图分类号:

杨倩, 杨俭. 8-甲氧补骨脂素药理作用研究进展[J]. 中国临床药理学与治疗学, 2014, 19(10): 1177-1182.

YANG Jian, YANG Qian. Advances in pharmacological research of 8-methoxypsoralen[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(10): 1177-1182.

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