胶质瘤中异常表达的lncRNAs的研究进展

doi:10.12092/j.issn.1009-2501.2018.05.017

摘要/Abstract

摘要：

随着全基因组和转录组测序技术的进步，越来越多的长链非编码RNA（lncRNAs）被发现。研究表明lncRNAs对胶质瘤的诊断、治疗和化疗预后具有重要意义。截至目前共有20多个异常表达的lncRNAs被证实与胶质瘤的发生发展密切相关。本文主要阐述这些公开报道异常表达的lncRNAs，以期为胶质瘤诊断、治疗和预后评价提供新的生物靶标。

关键词: 胶质瘤, 长链非编码RNA, 药理作用, 生物靶标

Abstract:

With the development of whole genome and transcriptome sequencing technologies, a growing body of long noncoding RNAs (lncRNAs) has been identified. It showed that lncRNAs were important for the diagnosis, treatment and prognosis of glioma. At present, more than 20 abnormal expression lncRNAs have been identified that may play a role in glioma pathogenesis. In this paper, we reviewed those lncRNAs in glioma in hope of helping to identify potential biomarkers and improve the diagnosis and the treatment of glioma.

Key words: glioma, lncRNAs, pharmacological effects, biomarkers

中图分类号:

R739

高元峰，李珊，刘林，欧阳荣. 胶质瘤中异常表达的lncRNAs的研究进展[J]. 中国临床药理学与治疗学, 2018, 23(5): 586-591.

GAO Yuanfeng, LI Shan, LIU Lin, OUYANG Rong. Research progress of abnormally expressed lncRNAs in glioma[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2018, 23(5): 586-591.

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