乙酰半胱氨酸牛磺酸镁盐对非酒精性脂肪性肝炎大鼠脂质代谢的影响

中国临床药理学与治疗学 ›› 2014, Vol. 19 ›› Issue (11): 1206-1210.

乙酰半胱氨酸牛磺酸镁盐对非酒精性脂肪性肝炎大鼠脂质代谢的影响

蔡兆斌¹, 王福根¹, 庄让笑¹, 方红英¹, 邵益丹¹, 席建军¹, 潘旭旺¹, 史婷婷¹, 梁伟峰²

¹ 浙江中医药大学附属杭州西溪医院,杭州310023,浙江;
² 浙江大学医学院附属第一医院,杭州310010,浙江

收稿日期:2013-09-26 修回日期:2014-10-29 出版日期:2014-11-26 发布日期:2014-12-09
通讯作者: 梁伟峰,男,教授,硕士生导师,研究方向:传染病临床与药物治疗。
作者简介:蔡兆斌,男,主任医师,研究方向:肝病药物的研发。 Tel: 0571-85463955 E-mail: wfg85463955@126.com
基金资助:
浙江省自然基金项目(Y2101449); 杭州市科技局项目(20140633B28,20130733Q30); 杭州市科技局项目(20130733Q30)

Effects of acetylcysteine taurine magnesium salt on lipid metabolism of NASH in rats

CAI Zhao-bin¹, WANG Fu-gen¹, ZHUANG Rang-xiao¹, FANG Hong-ying¹, SHAO Yi-dan¹, XI Jian-jun¹, PAN Xu-wang¹, SHI Ting-ting¹, LIANG Wei-feng²

¹ Xixi Hospital Affiliated to Zhejiang Chinese Medical University,Hangzhou 310023,Zhejiang,China;
² First Affiliated Hospital of Zhejiang University Medical College, Hangzhou 310010,Zhejiang,China

Received:2013-09-26 Revised:2014-10-29 Online:2014-11-26 Published:2014-12-09

摘要/Abstract

摘要： 目的观察乙酰半胱氨酸牛磺酸镁盐对高脂饮食所致非酒精性脂肪性肝炎(NASH)模型大鼠脂质代谢的影响。方法采用高脂饲料喂养12周复制大鼠NASH模型,成模后大鼠分为模型组、乙酰半胱氨酸牛磺酸镁盐低、中、高剂量治疗组和易善复阳性对照组。治疗8周后取血测定各组大鼠血清ALT、AST、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)。结果与NASH模型组相比,各治疗组大鼠血清ALT、AST、TC、TG、LDL-C含量均明显降低,HDL-C含量显著升高,差异具有统计学意义(P<0.05),其中乙酰半胱氨酸牛磺酸镁盐中、高剂量组改善尤为显著。结论乙酰半胱氨酸牛磺酸镁盐保护NASH大鼠作用通过降低血清转氨酶水平,改善血脂含量实现。

关键词: 乙酰半胱氨酸牛磺酸镁盐, 非酒精性脂肪性肝炎, 脂质代谢

Abstract: AIM: To study the effect of acetylcysteine taurine magnesium salt [(NAC·TA)Mg]on lipid metabolism in rats with non-alcoholic steatohepatitis (NASH). METHODS: 95 male SD rats were randomly divided into 2 groups:the normal group,the model group.The experimental rats were given fat rich diet.The model of NASH was established after 12 weeks. All the rats were put to death after 8 weeks treatment,plasma sample was collected for the content detection of serum ALT,AST,triglyceride(TG),total cholesterol(TC),the high-density lipoprotein cholesterol(HDL-C) and low density lipoprotein cholesterol(LDL-C).RESULTS: Compared with the model group,the contents of ALT,AST,TG,TC or LDL-C were significantly decreased, the conten of HDL-C was increased,the differences had remarkable significance(P<0.05 or P<0.01).CONCLUSION: (NAC·TA)Mg can obviously decrease the content of blood-fat in rats with NASH.

Key words: acetylcysteine taurine magnesium salt, non-alcoholic steatohepatitis, lipid metabolism

中图分类号:

R965.2

蔡兆斌, 王福根, 庄让笑, 方红英, 邵益丹, 席建军, 潘旭旺, 史婷婷, 梁伟峰. 乙酰半胱氨酸牛磺酸镁盐对非酒精性脂肪性肝炎大鼠脂质代谢的影响[J]. 中国临床药理学与治疗学, 2014, 19(11): 1206-1210.

CAI Zhao-bin, WANG Fu-gen, ZHUANG Rang-xiao, FANG Hong-ying, SHAO Yi-dan, XI Jian-jun, PAN Xu-wang, SHI Ting-ting, LIANG Wei-feng. Effects of acetylcysteine taurine magnesium salt on lipid metabolism of NASH in rats[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(11): 1206-1210.

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