突触再可塑性在脊髓损伤恢复中的作用

摘要/Abstract

摘要： 突触可塑性是用来描述突触传递效能的一种活动依赖性变化,其长时程改变可分为长时程增强(LTP)和长时程抑制(LTD)。再可塑性是突触可塑性的一种高阶形式,即通过前呈刺激活动依赖性调节LTP或LTD的诱导或表达。关于脊髓突触可塑性及其在脊髓损伤中的作用,国内外已有较多研究报道,近年来脊髓突触再可塑性的机制研究及其对脊髓损伤恢复的影响逐渐成为热点。本文主要对突触再可塑性及其在脊髓损伤恢复中的作用研究进行综述。

关键词: 脊髓损伤, 突触可塑性, 再可塑性

Abstract: The term synaptic plasticity describes the ability of excitatory synapse to undergo activity-dependent long-term changes in the efficacy of synaptic transmission. This change includes LTP and LTD. Metaplasticity is a high-order form of synaptic plasticity that regulates the expressions of LTP and LTD through prime stimulation. The synaptic plasticity in spinal cord and its role in the recovery after spinal cord injury have been widely reported in recent years, research on mechanism underlying metaplasticity and its role in the recovery after spinal cord injury has become a hotspot. And it will be focused in this review.

Key words: spinal cord injury, synaptic plasticity, metaplasticity

中图分类号:

R744

秦雯, 张艳, 汪萌芽. 突触再可塑性在脊髓损伤恢复中的作用[J]. 中国临床药理学与治疗学, 2014, 19(11): 1288-1293.

QIN Wen, ZHANG Yan, WANG Meng-ya. Roles of synaptic metaplasticity in the recovery after spinal cord injury[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(11): 1288-1293.

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