一个新型的代谢综合征调控靶点——类法尼醇X受体

中国临床药理学与治疗学 ›› 2014, Vol. 19 ›› Issue (11): 1312-1316.

一个新型的代谢综合征调控靶点——类法尼醇X受体

朱虹¹, 许竹梅², 肖健²

¹ 温州医科大学附属第一医院内分泌科, 温州医科大学;
² 药学院,温州 325000,浙江

收稿日期:2013-12-27 修回日期:2014-10-28 出版日期:2014-11-26 发布日期:2014-12-09
作者简介:朱虹,女,硕士,研究方向:代谢综合征。 Tel:13758712421 E-mail: xiangxiang104@163.com
基金资助:
浙江省自然科学基金资助项目(Y2110328)

A new regulatory target of the metabolic syndrome :the farnesoid X receptor

ZHU Hong¹, XU Zhu-mei², XIAO Jian²

¹ Department of Endocrinology, the First Affiliated Hospital of Wenzhou Medical University;
² School of Pharmacy, Wenzhou Medical Universyty, Wenzhou 325000,Zhejiang,China

Received:2013-12-27 Revised:2014-10-28 Online:2014-11-26 Published:2014-12-09

摘要/Abstract

摘要： 类法尼醇X受体(farnesoid X receptor,FXR)是一种胆汁酸的核受体,在胆汁酸、血脂和糖代谢中具有重要调节作用,从而与代谢综合征密切相关,可能成为一个新型的治疗代谢综合征的调控靶点。本文将就 FXR与胆汁酸代谢和糖脂代谢的研究进展进行详细论述。

关键词: 类法尼醇X受体, 胆汁酸, 脂代谢, 糖代谢

Abstract: The farnesoid X receptor(FXR) is a nuclear receptor of bile acids, which plays an important role in bile acid regulation, lipid and glucose homeostasis. It associates with metabolic syndrome closely. Thus, FXR is probably a new regulatory target in the treatment of metabolic syndrome.This paper discusses the research progress about the FXR and bile acid regulation, lipid and glucose homeostasis.

Key words: FXR, bile acid, lipid metabolism, glucose metabolism

中图分类号:

R589

朱虹, 许竹梅, 肖健. 一个新型的代谢综合征调控靶点——类法尼醇X受体[J]. 中国临床药理学与治疗学, 2014, 19(11): 1312-1316.

ZHU Hong, XU Zhu-mei, XIAO Jian. A new regulatory target of the metabolic syndrome :the farnesoid X receptor[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(11): 1312-1316.

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