急性高容血液稀释对术后认知功能的影响

中国临床药理学与治疗学 ›› 2014, Vol. 19 ›› Issue (11): 1316-1320.

• 综述与讲座 • 上一篇

急性高容血液稀释对术后认知功能的影响

苏永俊^{1, 2}, 郭建荣², 金孝岠¹

¹ 皖南医学院弋矶山医院麻醉科,芜湖 241001,安徽;
² 上海市浦东新区公利医院麻醉科,上海 200135

收稿日期:2013-07-12 修回日期:2014-10-31 出版日期:2014-11-26 发布日期:2014-12-09
通讯作者: 郭建荣,男,博士,主任医师,教授,硕导,研究方向:临床麻醉与血液保护。Tel: 13671834826 E-mail: jianrguo@126.com
作者简介:苏永俊,男,在读硕士,研究方向:临床麻醉与应激。 Tel: 18321486900 E-mail: 175670378@qq.com
基金资助:
上海市浦东新区卫生系统领先人才项目(PWR12013-03)

Effect of acute hypervolemic hemodilution on postoperative cognitive function

SU Yong-jun^{1, 2}, GUO Jian-rong², JIN Xiao-ju¹

¹ Anesthesiology Department of the Affiliated Yijishan Hospital of Wannan Medical College,Wuhu 241001,Anhui,China;
² Anesthesiology Department of Shanghai Pudong New Area Gongli Hospital,Shanghai 200135,China

Received:2013-07-12 Revised:2014-10-31 Online:2014-11-26 Published:2014-12-09

摘要/Abstract

摘要： 急性高容血液稀释(AHH)可有效维持术中血流动力学和内环境稳定,改善微循环,优化血

关键词: 急性高容血液稀释, 认知功能, 血液保护

Abstract: Acute hypervolemic hemodilution(AHH) can effectively maintain hemodynamic stable and homeostasis,improve the perfusion of microcirculation,optimize hemorhcological condition,reduce the need for homologous blood transfusion and transfusion reactions.The pathogenesy of postoperative cognitive dysfunction(POCD) is complex,relates to the changes of multisystemic function,this article summarizes the effects of acute hypervolemic hemodilution on cerebral oxygenation metabolism,hemodynamics,pulmonary function,blood coagulation,immunological function etc,in order to expound the correlations between acute hypervolemic hemodilution and postoperative cognitive dyfunction.

Key words: acute hypervolemic hemodilution, cognitive function, blood conservation

中图分类号:

R614

苏永俊, 郭建荣, 金孝岠. 急性高容血液稀释对术后认知功能的影响[J]. 中国临床药理学与治疗学, 2014, 19(11): 1316-1320.

SU Yong-jun, GUO Jian-rong, JIN Xiao-ju. Effect of acute hypervolemic hemodilution on postoperative cognitive function[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(11): 1316-1320.

参考文献 33

[1]	薛张纲. 输血与自体输血[M]//庄心良,曾因明,陈伯銮,主编.现代麻醉学.3版.北京:人民卫生出版社,2003: 1738-1739.
[2]	王婷,薛张纲,蒋豪.老年患者术中6%羟乙基淀粉急性高容量血液稀释的可行性[J].中华麻醉学杂志,2003,23(4):260-263.
[3]	Bittner EA,Yue Y,Xie Z.Brief review:anesthetic neurotoxicity in the elderly,cognitive dysfunction and Alzheimer's disease[J].Can J Anaesth,2011,58(2):216-223.
[4]	Funder KS,Steinmetz J,Rasmussen LS.Methodological issues of postoperative cognitive dysfunction research[J].Semin Cardiothorac Vasc Anesth,2010,14(2):119-122.
[5]	Jungwirth B,Zieglgänsberger W,Kochs E,et al.Anesthesia and postoperative cognitive dysfunction (POCD)[J].Mini Rev Med Chem,2009,9(14):1568-1579.
[6]	Monk TG,Weldon BC,Garvan CW,et al.Predictors of cognitive dysfunction after major noncardiac surgery[J].Anesthesiology,2008,108(1):18-30.
[7]	Damuleviciene G,Lesauskaite V,Macijauskiene J.Postoperative cognitive dysfunction of older surgical patients[J].Medicina (Kaunas),2010,46(3):169-175.
[8]	Kravitz BA,Corrada MM,Kawas CH.Elevated C-reactive protein levels are associated with prevalent dementia in the oldest-old[J].Alzheimers Dement,2009,5(4):318-323.
[9]	Li YC,Xi CH,An YF,et al.Perioperative inflammatory response and protein S-100β concentrations - relationship with post-operative cognitive dysfunction in elderly patients[J].Acta Anaesthesiol Scand,2012,56(5):595-600.
[10]	Hare GM,Mazer CD,Hutchison JS,et al.Severe hemodilutional anemia increase cerebral tissue injury following acute neurotrauma[J].J Appl Physiol,2007,103(3):1021-1029.
[11]	Tango HK,Schmidt AP,Mizumoto N,et al.Low hematocrit levels increase intracranial pressure in an animal model of cryogenic brain injury[J].J Trauma,2009,66(3):720-726.
[12]	滕如阳,张卫,李莉.诱导期急性高容量血液稀释在老年患者的应用[J].临床麻醉学杂志,2005,21(8):564-565.
[13]	于布为,顾敏杰,薛庆生,等.急性超容性血液稀释对氧供、氧耗、循环血容量和血管外肺水的影响[J].临床麻醉学杂志,2003,19(1):23-26.
[14]	Kumar A,Anel R,Bunnell E,et al.Effect of large volume infusion on left ventricular volumes,performance and contractility parameters in normal volunteers[J].Intensive Care Med,2004,30(7):1361-1369.
[15]	苏鹏,何晓峰,姚颖.6%羟乙基淀粉130/0.4对老年食管癌手术患者肾功能的影响[J].医药导报,2011,30(8):1030-1033.
[16]	王玲玲,徐世元,许平,等.肺科手术中扩容对血管外肺水和肺渗透性的影响[J].广东医学,2007,28(12):1937-1938.
[17]	de Jonge E,Levi M.Effects of different plasma substitutes on blood coagulation: a comparative review[J].Crit Care Med,2001,29(6):1261-1267.
[18]	Xiao H,Du B,Xu H.Application of acute extreme hypervolemic hemodilution in spine surgery[J].Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi,2007,21(10):1090-1093.
[19]	张霞,魏蔚,郑祥德,等.不同液体超容量血液稀释对凝血功能的影响[J].中国输血杂志,2006,19(2):121-123.
[20]	单闯,吴国荣,张顺,等.急性高容量血液稀释对全髋关节置换术患者血小板膜糖蛋白表达的影响[J].中华麻醉学杂志,2003,23(9):648-650.
[21]	周春莲,周纲,陈玲阳.6%羟乙基淀粉200/0.5急性高容量血液稀释对2型糖尿病患者血液流变学的影响[J].中国临床药理学与治疗学,2011,16(1):88-92.
[22]	Franke A,Lante W,Kurig E,et al.Hyporesponsiveness of T cell subsets after cardiac surgery : a product of altered cell function or merely a result of absolute cell count changes in peripheral blood?[J].Eur J Cardiothorac Surg,2006,30(1):64-71.
[23]	Kim J,Konyalian V,Huynh R,et al.Identification of predictive factors for perioperative blood transfusion in colorectal resection patient[J].Int J Colorectal Dis, 2007,22(12):1493-1497.
[24]	陈力,王天龙.不同程度急性高容量血液稀释对全麻病人内脏氧合和全身炎性反应的影响[J].临床麻醉学杂志,2008,24(1):5-7.
[25]	刘慧慧,彭雪梅,林永新,等.急性高容量血液稀释对脊柱手术患者超敏C反应蛋白的影响[J].南方医科大学学报,2011,31(6):1063-1065.
[26]	彭云水,褚海辰,贾慧群,等.术前急性高容量血液稀释对肿瘤病人围术期T淋巴细胞免疫功能的影响[J].中华麻醉学杂志,2000,20(9):529-531.
[27]	董铁立,马孝武,李廷坤,等.术前急性高容量血液稀释对开胸术老年患者血液动力学、血乳酸和白介素-6水平的影响[J].中华麻醉学杂志,2007,27(2):184-185.
[28]	毛琛璐,邹蓉,钱燕宁.羟乙基淀粉及琥珀酰明胶对成人静脉血辅助性T淋巴细胞分化的影响[J].临床麻醉学杂志,2008,24(2):97-99.
[29]	Tian J,Lin X,Guan R,et al.The effects of hydroxyethyl starch on lung capillary permeability in endotoxic rats and possible mechanisms[J].Anesth Analg,2004,98(3):768-774.
[30]	Feng X,Yan W,Liu X,et al.Effects of hydroxyethyl starch 130/0.4 on pulmonary capillary leakage and cytokines production and NF-kappaB activation in CLP-induced sepsis in rats[J].J Surq Res,2006,135(1):129-136.
[31]	Georgiadis D,Berger A,Kowatschev E,et al.Predictive value of S-100 beta and neuron-spelific enolase levels for adverse neurologic outcome after cardiac surgery[J].J Thorac cardiovasc surg,2000,119(1):138-147.
[32]	王黎. 急性高血容量稀释联合控制性降压对老年患者术后认知功能的影响[D].沈阳:中国医科大学,2010.
[33]	汪平,王磊,武庆平.限制性输血对老年患者围手术期脑氧供需平衡及认知功能的影响[J].华中科技大学学报(医学版),2012,41(6):740-744.

急性高容血液稀释对术后认知功能的影响

Effect of acute hypervolemic hemodilution on postoperative cognitive function

PDF (PC)

可视化

被引次数

摘要/Abstract

引用本文

使用本文

参考文献 33

相关文章 15

编辑推荐

Metrics

本文评价

[1]	陈健, 兰宇, 吴勇, 沈伯雄. 肠道菌群紊乱对吸入麻醉患者术后认知功能障碍的影响[J]. 中国临床药理学与治疗学, 2022, 27(6): 639-644.
[2]	厉永亮, 林海燕, 张玲玲, 董伊隆. 地佐辛自控镇痛泵术前应用对老年下肢骨折患者应激反应及认知功能的影响[J]. 中国临床药理学与治疗学, 2022, 27(3): 302-306.
[3]	倪渊博, 张昕, 李仪, 刘存明. 麻醉及镇痛药物与认知功能[J]. 中国临床药理学与治疗学, 2022, 27(12): 1365-1374.
[4]	周敏敏, 余露, 韩超, 顾达民, 雷道赟. 人类胆固醇酯转移蛋白rs5882基因多态性与围术期神经认知功能紊乱的相关性[J]. 中国临床药理学与治疗学, 2021, 26(7): 768-774.
[5]	俞陈陈，刘树群，刘建龙，曹红，刘雪娇，蔡茜茜. 姜黄素对高血压病大鼠全脑缺血再灌注时海马神经元损伤及皮质酮、SGK1表达的影响[J]. 中国临床药理学与治疗学, 2019, 24(7): 737-743.
[6]	张睿. 右美托咪定改善缺血性脑血管病患者术后认知功能障碍和注意网络功能的临床研究[J]. 中国临床药理学与治疗学, 2019, 24(7): 815-820.
[7]	胡德凤，王轶虎，龙小宇，王广水. 甘麦大枣汤加减方联合认知行为干预对精神分裂症超高危人群的干预作用及对认知功能、生活质量及血清5-HT、MT、TSH水平的影响[J]. 中国临床药理学与治疗学, 2019, 24(5): 546-553.
[8]	喻君，金孝岠，郭建荣，曹亚，鲁美静，常燕，周玉梅，周炜. 不同时机应用氨甲环酸对体外循环心脏瓣膜手术患者凝血功能及出血量的影响[J]. 中国临床药理学与治疗学, 2019, 24(12): 1415-1420.
[9]	陈娟燕，宋水江，徐冬娟，徐琼，李鸿飞. 法舒地尔联合瑞舒伐他汀治疗血管性痴呆对认知功能、C-反应蛋白及氧化应激的影响[J]. 中国临床药理学与治疗学, 2018, 23(10): 1153-1158.
[10]	莫亚莉，夏泳，刘义，陶云海，金曼. 石杉碱甲联合艾司西酞普兰对抑郁症临床疗效及认知功能的影响[J]. 中国临床药理学与治疗学, 2017, 22(9): 1040-1044.
[11]	邓迎丰. 右美托咪定在老年患者内镜黏膜下剥离术中的应用[J]. 中国临床药理学与治疗学, 2017, 22(5): 580-583.
[12]	王清华，储照虎，许业松，赵守财，方芳，孙爱萍. 头针治疗对脑卒中认知障碍患者MoCA评分和血清Hcy水平的影响[J]. 中国临床药理学与治疗学, 2017, 22(2): 165-169.
[13]	宋秀娟，林永坚，王丽娜，徐惠琴，刘小利. 奥拉西坦联合复方苁蓉益智胶囊治疗脑白质疏松认知障碍的临床效果观察[J]. 中国临床药理学与治疗学, 2017, 22(2): 184-189.
[14]	尤匡掌，陈斌，包倩倩. 七氟烷联合丙泊酚对老年非小细胞肺癌胸腔镜切除术后认知功能及血清氧化应激水平的影响[J]. 中国临床药理学与治疗学, 2017, 22(2): 190-193.
[15]	左蕾, 刘丹彦, 李琪英. 姜黄素对七氟醚吸入后老年大鼠认知功能的影响[J]. 中国临床药理学与治疗学, 2014, 19(6): 638-643.