宫颈环形电切术治疗高级别宫颈上皮内瘤变的远期疗效分析

中国临床药理学与治疗学 ›› 2014, Vol. 19 ›› Issue (12): 1411-1415.

宫颈环形电切术治疗高级别宫颈上皮内瘤变的远期疗效分析

张楠, 何莲芝

皖南医学院第一附属医院妇产科,芜湖 241001,安徽

收稿日期:2013-08-07 修回日期:2014-07-07 发布日期:2020-07-20
通讯作者: 何莲芝,通信作者,女,主任医师,硕士研究生导师,研究方向:妇科肿瘤。Tel:0553-5739563 E-mail:429094335@qq.com
作者简介:张楠,女,硕士研究生,主治医师,研究方向:妇科肿瘤。Tel:13956661160 E-mail:easy_nan@163.com

Analysis of long-dated security and effectiveness for high-grade cervical intraepithelial neoplasia with loop electrosurgical excision procedure

ZHANG Nan, HE Lian-zhi

Department of Gynecology and Obstetrics, the First Affiliated Hospital of Wannan Medical College, Wuhu 241001, Anhui, China

Received:2013-08-07 Revised:2014-07-07 Published:2020-07-20

摘要/Abstract

摘要： 目的: 探讨宫颈环形电切术(LEEP)治疗高级别宫颈上皮内瘤变(CINII、CINIII)中的安全性与有效性。方法: 总结分析2008年1月至2008年12月在皖南医学院第一附属医院经LEEP治疗后87例高级别宫颈上皮内瘤变患者5年的随访资料,分析患者的病情转归。结果: 随访5年内治愈85例(97.7%),复发2例(2.3%);二分类Logistic回归分析显示:年龄是术后复发的危险因素(P<0.05),累及腺体与否对术后复发无显著影响(P>0.05);5例术前无生育史者术后均自然受孕,受孕率为100%,无不良妊娠结局,均择期剖宫产分娩,5例因非意愿怀孕行人工流产术,1例稽留流产。结论: LEEP治疗CINII、CINIII是安全、有效的,不影响妊娠结局。TCT联合HPV检测是术后随访的可靠方法。

关键词: 宫颈环形电切术, 宫颈上皮内瘤变, 随访, 妊娠结局

Abstract: AIM: To evaluate the security and effectiveness of loop electrosurgical excision procedure (LEEP) for high-grade cervical intraepithelial neoplasia(CINII,CINIII). METHODS: To analyze the clinical information of 87 patients whose pathology diagnosed as CINII,CINIII through LEEP in the First Affiliated Hospital of Wannan Medical College between January 2008 and December 2008 for 5 years and their disease outcome. RESULTS: During 5 years follow-up, 85 cases cured(97.7%) and 2 cases recurred(2.3%);Binary logistic regression analysis showed that age was the risk factor of recrudescence(P<0.05), but no significant relationship between gland involvement and recrudescence of CINII,CINIII after LEEP(P>0.05);5 patients who had no fertility history of preoperative owned natural conception.The conception rate was 100%.All of them had cesarean delivery(1 case/twice),without adverse pregnancy outcomes.5 cases received induced abortion, who did not have fertility desires pregnancy.1 case had missed abortion. CONCLUSION: LEEP is a secure and effectiveness treatment to CINII,CINIII and does not affect the pregnancy outcome.TCT combined with HPV test is a reliable method to postoperative follow-up.

Key words: cervical intraepithelial neoplasia, loop electrosurgical excision procedure, follow-up, pregnancy outcome

中图分类号:

R711

张楠, 何莲芝. 宫颈环形电切术治疗高级别宫颈上皮内瘤变的远期疗效分析[J]. 中国临床药理学与治疗学, 2014, 19(12): 1411-1415.

ZHANG Nan, HE Lian-zhi. Analysis of long-dated security and effectiveness for high-grade cervical intraepithelial neoplasia with loop electrosurgical excision procedure[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(12): 1411-1415.

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