猕猴桃根多糖脂质体对D-半乳糖胺所致小鼠实验性急性肝损伤的药效作用

中国临床药理学与治疗学 ›› 2014, Vol. 19 ›› Issue (6): 611-614.

猕猴桃根多糖脂质体对D-半乳糖胺所致小鼠实验性急性肝损伤的药效作用

李晓黎¹, 戴文芸^{2, 3}, 石森林², 吴瑾瑾², 朱雨晴²

¹绍兴市人民医院, 绍兴 312000, 浙江;
²浙江中医药大学, 杭州 310053, 浙江;
³杭州市江干区四季青街道社区卫生服务中心, 杭州 310016, 浙江

收稿日期:2013-12-18 修回日期:2014-05-20 发布日期:2014-07-01
通讯作者: 石森林, 男, 博士, 教授, 博士生导师。
作者简介:李晓黎, 女, 主管药师, 研究方向:医院药学。Tel: 13587320312 E-mail:shaoxinglixiaoli@126.com
基金资助:
浙江省自然科学基金(Y2101417);浙江省科技计划重点项目(2008C23068)

Pharmacodynamics effects of APPS Liposome on acute liver injury induced by D-galactosamine in experimental mice

LI Xiao-li¹, DAI Wen-yun^{2, 3}, SHI Sen-lin², WU Jin-jin², ZHU Yu-qing²

¹Shaoxing People’s Hospital, Shaoxing 312000, Zhejiang, China;
²Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang, China; ³Sijiqing Street Community Health Center, Hangzhou 310016, Zhejiang, China

Received:2013-12-18 Revised:2014-05-20 Published:2014-07-01

摘要/Abstract

摘要： 目的: 研究猕猴桃根多糖(APPS)脂质体对D-半乳糖胺所致小鼠急性肝损伤的保护作用。方法: 采用D-半乳糖胺所致小鼠急性肝损伤模型, 以联苯双酯为对照药, 以小鼠血清中ALT、AST等为指标, 评价APPS脂质体的抗急性肝损伤作用。结果: APPS脂质体口服液高剂量(200 mg/kg)对D-半乳糖胺所致小鼠急性肝损伤药效作用结果显著(P<0.05 或P<0.01)。低剂量(50 mg/kg)对各肝损伤模型的治疗则无显著性意义(P>0.05)。结论: APPS脂质体口服液对小鼠急性肝损伤有较好的保护作用。

关键词: APPS脂质体, D-半乳糖胺所致肝损伤, 防治作用

Abstract: AIM : To study the preventive and therapeutic effects of APPS Liposome on mice acute liver injury induced by D-galactosamine.METHODS: D-galactosamine was given to establish the acute liver damaged mouse models. ALT, AST in mice blood were examined as indexes to study on the anti-acute liver injury effect of APPS Polyphase liposome oral liquid, with bifendate as a control drug.RESULTS:High dosage of APPS Polyphase liposome(200 mg/kg)have a significant effect on the acute liver damaged mice models(P<0.05 or P<0.01), low dosage(50 mg/kg)has no significant effect on the models(P>0.05).CONCLUSION: The results indicated that preventive and therapeutic effects of APPS Polyphase Liposome on mice acute liver injury are significant.

Key words: APPS liposome, D-galactosamine induced liver injury, preventive and therapeutic effect 本

中图分类号:

R965.2

李晓黎, 戴文芸, 石森林, 吴瑾瑾, 朱雨晴. 猕猴桃根多糖脂质体对D-半乳糖胺所致小鼠实验性急性肝损伤的药效作用[J]. 中国临床药理学与治疗学, 2014, 19(6): 611-614.

LI Xiao-li, DAI Wen-yun, SHI Sen-lin, WU Jin-jin, ZHU Yu-qing. Pharmacodynamics effects of APPS Liposome on acute liver injury induced by D-galactosamine in experimental mice[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(6): 611-614.

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