BSG基因多态性与中国汉族人群类风湿性关节炎的遗传易感性研究

中国临床药理学与治疗学 ›› 2014, Vol. 19 ›› Issue (7): 780-784.

BSG基因多态性与中国汉族人群类风湿性关节炎的遗传易感性研究

郭韧¹, 黄攀豪¹, 刘作良²

¹ 中南大学湘雅三医院药剂科,长沙 410013,湖南;
² 中南大学湘雅三医院急危重症科,长沙 410013,湖南

收稿日期:2013-08-14 修回日期:2014-06-23 发布日期:2014-07-21
通讯作者: 刘作良,男,硕士,主治医师,研究方向:病理生理学。 Tel: 0731?8861870 　E?mail: iculzl@sina.com.
作者简介:郭韧,男,博士,助理研究员,研究方向:临床药学。 Tel: 0731-88618455 E-mail: grfw2004@126.com
基金资助:
国家自然科学基金项目(81000120)

Association between BSG gene polymorphism and rheumatoid arthritis susceptibility

GUO Ren¹, HUANG Pan-hao¹, LIU Zuo-liang²

¹ Department of Pharmacy, the Third Xiangya Hospital, Central South University, Changsha 410013, Hunan, China;
² Department of ICU, the Third Xiangya Hospital, Central South University, Changsha 410013,Hunan,China

Received:2013-08-14 Revised:2014-06-23 Published:2014-07-21

摘要/Abstract

摘要： 目的探讨BSG(Basigin)基因多态性与中国汉族人群类风湿性关节炎发病之间的相关性。方法收集196例类风湿性关节炎患者和249例健康人群,应用PCR-RFLP的分析方法,对BSG基因T-10292A多态性进行基因分型,用ELISA法检测血清中可溶性CD147(sCD147)的表达。结果病例组与对照组BSG基因T-10292A多态基因型的分布差异存在着统计学意义 (P<0.05)。与正常对照组相比,类风湿性关节炎患者血清中sCD147的浓度显著升高。与其他基因型患者相比,TT基因型患者,其sCD147的浓度最低。结论 BSG基因多态性与中国汉族人群类风湿性关节炎的发病可能相关。

关键词: 类风湿性关节炎, BSG, CD147, 多态性

Abstract: AIM: To investigate the association of BSG-10292T/A rs8259 polymorphisms with rheumatoid arthritis susceptibility in a Chinese Han population. METHODS: We performed a case-control analysis including a total of 196 cases and 249 healthy controls.Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to genotype the SNP.The expression of sCD147 in serum was detected. RESULTS:Our result indicated that there is significant difference in the allele frequencies between the RA cases and controls accompanied with a significant difference in sCD147.CONCLUSION: BSG-10292T/A polymorphism is associated with rheumatoid arthritis susceptibility in Chinese Han population.

Key words: rheumatoid arthritis (RA), BSG, CD147, polymorph

中图分类号:

R34
R596

郭韧, 黄攀豪, 刘作良. BSG基因多态性与中国汉族人群类风湿性关节炎的遗传易感性研究[J]. 中国临床药理学与治疗学, 2014, 19(7): 780-784.

GUO Ren, HUANG Pan-hao, LIU Zuo-liang. Association between BSG gene polymorphism and rheumatoid arthritis susceptibility[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(7): 780-784.

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