强直性脊柱炎骨桥形成与炎症关系的研究进展

摘要/Abstract

摘要： 强直性脊柱炎(ankylosing spondylitis,AS)是全身性炎症性疾病。炎症和骨桥形成是AS典型病理变化的两个阶段,炎症是AS的最主要特征,骨桥形成是AS致残的主要因素,以往观点认为,炎症促发了骨桥形成,但临床研究发现控制炎症似乎不能阻滞关节和脊柱发生强直,二者之间的关系十分模糊。本文就近十多年来关于AS骨桥形成机制及炎症与骨桥形成关系的研究进展作一综述。

关键词: 强直性脊柱炎, 炎症, 骨桥形成

Abstract: Ankylosing spondylitis(AS)is a systemic inflammatory diseases. Inflammation and bone bridge formation are two stages of the AS typical pathological changes.Inflammation is the main character and bone bridge formation is the primary cause of joint deformity. It was considered that inflammation contributed to the formation of bone bridge,but clinical studies had found that ankylosis could not been stopped after the control of inflammation. The relationship between them seems be very vague. This article summarized the research of the development about bone bridge formation and the relationship between bone bridge formation and inflammation in recent decades.

Key words: ankylosing spondylitis, inflammation, bone bridge formation

中图分类号:

R593.23

王田玲, 徐亮. 强直性脊柱炎骨桥形成与炎症关系的研究进展[J]. 中国临床药理学与治疗学, 2015, 20(1): 101-105.

WANG Tian-ling, XU Liang. Research progress of the relationship between bone bridge formation and inflammation in patients with ankylosing spondylitis[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2015, 20(1): 101-105.

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