甲巯咪唑致严重粒细胞缺乏临床分析

中国临床药理学与治疗学 ›› 2015, Vol. 20 ›› Issue (3): 293-295.

甲巯咪唑致严重粒细胞缺乏临床分析

张杰, 肖艳, 牛秋霞, 宋趣兰

中国人民解放军第153中心医院内分泌科,郑州 450042,河南

收稿日期:2013-07-22 修回日期:2014-11-18 发布日期:2015-04-08
作者简介:张杰,男,博士,研究方向:中西医结合临床工作。Tel: 15936279515 E-mail: doctorzhangjie@126.com

Clinical analysis for severe agranulocytosis caused by methimazole

ZHANG Jie, XIAO Yan, NIU Qiu-xia, SONG Qu-lan

Department of Endocrinology,No. 153 Central Hospital of People's Liberation Army,Zhengzhou 450042,Henan,China

Received:2013-07-22 Revised:2014-11-18 Published:2015-04-08

摘要/Abstract

摘要： 甲巯咪唑是甲状腺机能亢进症的一线治疗药物,粒细胞缺乏是其少见但严重的副作用,可预测性差。通过分析应用甲巯咪唑致严重粒细胞缺乏症的临床资料,探讨其临床特点、发生机制及预防诊疗措施。分析发现抗甲状腺药物用药过程中特别是治疗初期,应高度警惕粒缺的发生。

关键词: 甲状腺机能亢进, 甲巯咪唑, 粒细胞缺乏症

Abstract: Methimazole is the first-line treatment drug of hyperthyroidism. Agranulemia is a rare but serious side effect of methimazole and has poor predictability. Through the clinical data analysis for severe agranulemia caused by methimazole to investigate the clinical characteristics, mechanism and prevention measures of the disease. During ATD medication, particularly early treatment, it should be highly alert to the occurrence of agranulemia.

Key words: hyperthyroidism, methimazole, agranulemia

中图分类号:

R969.3

张杰, 肖艳, 牛秋霞, 宋趣兰. 甲巯咪唑致严重粒细胞缺乏临床分析[J]. 中国临床药理学与治疗学, 2015, 20(3): 293-295.

ZHANG Jie, XIAO Yan, NIU Qiu-xia, SONG Qu-lan. Clinical analysis for severe agranulocytosis caused by methimazole[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2015, 20(3): 293-295.