VEGF和MMP-9与缺血性脑卒中关系的研究进展

摘要/Abstract

摘要： 缺血性脑卒中具有极高的发病率、致残率和致死率,在危害身体健康的同时,给家庭甚至社会经济及国民生存质量带来了沉重的负担。近些年来,血管内皮生长因子(vascular endothelial growth factor, VEGF)和血清基质金属蛋白酶-9(matrix metalloproteinase-9, MMP-9)在缺血性脑卒中的研究成为国内外新的热点。一系列研究显示,缺血性脑卒中事件一旦发生,受累的颅内动脉所支配区域的脑组织出现缺血、缺氧,在低氧刺激及炎性介质的作用下VEGF和MMP-9表达上调,两者的表达水平与神经功能缺损程度及梗死面积密切相关,参与缺血性脑卒中的发展过程及血管新生,可评估患者病情严重程度及预后。

关键词: 缺血性脑卒中, VEGF, MMP-9, 缺血, 血管新生

Abstract: Ischemic stroke is one of the major diseases which cause serious damage to the human health. It has a high incidence, morbidity and mortality, brings heavy burden to the family even the social economy and the national quality of life. In recent years, vascular endothelial growth factor (VEGF) and serum matrix metalloproteinases 9 (MMP-9) in ischemic stroke become a new hot spot in the world. A series of studies shown that once the ischemic stroke happened, under the condition of ischemia and hypoxia, the expression level of VEGF and MMP-9 upregulated through hypoxic stimulus and inflammatory medium. VEGF and MMP-9 were also closely related to the nerve function defect degree and the infarction size, which participated in the development process of the ischemic stroke and angiogenesis, and might be a method to evaluate severity and prognosis with ischemic stroke.

Key words: ischemic stroke, VEGF, MMP-9, ischemia, angiogenesis

中图分类号:

R743

万梅, 周志明. VEGF和MMP-9与缺血性脑卒中关系的研究进展[J]. 中国临床药理学与治疗学, 2015, 20(3): 344-348.

WAN Mei, ZHOU Zhi-ming. Research progress in effects of VEGF and MMP-9 on ischemic stroke[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2015, 20(3): 344-348.

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