补气活血颗粒对链脲霉素诱导的1型糖尿病小鼠糖脂代谢的影响

中国临床药理学与治疗学 ›› 2015, Vol. 20 ›› Issue (4): 409-413.

补气活血颗粒对链脲霉素诱导的1型糖尿病小鼠糖脂代谢的影响

陈永荣¹, 钟凯龙², 洪浩²

¹安徽省六安市中医院药剂科,六安 237006,安徽;
²中国药科大学药理教研室,南京210009,江苏

收稿日期:2014-11-19 修回日期:2015-01-17 发布日期:2015-05-07
通讯作者: 洪浩,男,教授,博士生导师,研究方向:神经与内分泌药理。Tel: 025-86185227 E-mail: honghao@cpu.edu.cn
作者简介:陈永荣,女,副主任药师,研究方向:临床药学、医院药事管理。Tel: 13966269826 E-mail: cyr9826@126.com

Effects of buqihuoxue particles on glucose and lipid metabolism in streptozotocin-induced type 1 diabetes in mice

CHEN Yong-rong¹, ZHONG Kai-long², HONG Hao²

¹ Department of Pharmacy, Traditional Chinese Medical Hospital of Lu'an, Lu'an 237006,Anhui, China;
² Department of Pharmacology, China Pharmaceutical University, Nanjing 210009, Jiangsu, China

Received:2014-11-19 Revised:2015-01-17 Published:2015-05-07

摘要/Abstract

摘要： 目的: 研究补气活血颗粒对链脲霉素(streptozotocin,STZ)诱导的1型糖尿病小鼠糖脂代谢的影响。方法: 单次尾静脉注射链脲霉素(170 mg/kg)建立1型糖尿病小鼠模型,挑选血糖值≥11.1 mmol/L 的小鼠,分组。连续灌胃给药4周,检测每周空腹血糖(FBG)水平,并于给药4周后测定甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平。结果: 给药4周过程中,补气活血颗粒各给药组动物每周空腹血糖值与同期阴性对照组血糖值相比均有降低趋势,但变化相近(P>0.05);给药4周后,与阴性对照组相比,补气活血颗粒各给药组动物血清甘油三酯和低密度脂蛋白胆固醇水平有降低趋势,血清高密度脂蛋白胆固醇水平有升高趋势,但变化相近(P>0.05)。值得注意的是,补气活血颗粒中、高剂量组动物血清总胆固醇水平显著降低(P<0.05)。结论: 补气活血颗粒对1型糖尿病小鼠的糖脂代谢有改善趋势,但效应不显著,其中,对总胆固醇有显著降低作用。

关键词: 补气活血颗粒, 链脲霉素, 1型糖尿病, 糖脂代谢

Abstract: AIM: To investigate the effects of buqihuoxue particles on glucose and lipid metabolism in streptozotocin (STZ)-induced type 1 diabetes in mice.METHODS: Mice were intravenously injected once with STZ (170 mg/kg) to induce experimental type 1 diabetes characterized by hyperglycemia(Fasting blood glucose, FBG≥11.1 mmol/L). After grouping, diabetic mice were intragastrically administered with buqihuoxue particles for 4 weeks. FBG was measured every week, and serum triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were determined after 4 weeks of treatment.RESULTS: During the 4 weeks of treatment, the FBG level of all drug treatment groups gradually decreased but the decrease was statistically insignificant(P>0.05) compared with vehicle treatment group. Treatment with buqihuoxue particles led to a trend toward decreases in the levels of TG and LDL-C but increase in HDL-C level (P>0.05). Importantly, buqihuoxue particles (middle dose and high dose) significantly decreased TC level in type 1 diabetic mice (P<0.05).CONCLUSION: Buqihuoxue particles have a trend toward amelioration of glucose and lipid metabolism disorder, especially, it significantly decreases TC level.

Key words: buqihuoxue particles, streptozocin, type 1 diabetes, glucose and lipid metabolism

中图分类号:

R965.2

陈永荣, 钟凯龙, 洪浩. 补气活血颗粒对链脲霉素诱导的1型糖尿病小鼠糖脂代谢的影响[J]. 中国临床药理学与治疗学, 2015, 20(4): 409-413.

CHEN Yong-rong, ZHONG Kai-long, HONG Hao. Effects of buqihuoxue particles on glucose and lipid metabolism in streptozotocin-induced type 1 diabetes in mice[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2015, 20(4): 409-413.

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