舒康汤治疗慢性盆腔炎的实验研究

中国临床药理学与治疗学 ›› 2015, Vol. 20 ›› Issue (5): 510-513.

舒康汤治疗慢性盆腔炎的实验研究

吴伟平¹, 赖唐秀¹, 段志芳²

¹湖州市妇幼保健院妇产科, 湖州 313000,浙江;
²浙江省湖州市中医院妇科, 湖州 313000,浙江

收稿日期:2015-04-30 修回日期:2015-05-12 发布日期:2015-06-11
作者简介:吴伟平,女,本科,副主任医师,主要从事妇科炎症诊治及各类计划生育手术。Tel: 13706528838 E-mail: wwp8838@126.com

Experimental study on Shukang Soup in treatment of chronic pelvic inflammatory disease

WU Wei-ping¹, LAI Tang-xiu¹, DUAN Zhi-fang²

¹ Huzhou Maternal and Child Health Care Center of Zhejiang Province, Huzhou 313000, Zhejiang,China;
² Huzhou Hospital of Traditional Chinese Medicine of Zhejiang Province, Huzhou 313000, Zhejiang,China

Received:2015-04-30 Revised:2015-05-12 Published:2015-06-11

摘要/Abstract

摘要： 目的: 观察舒康汤对慢性盆腔炎的影响,并初探其可能作用机制。方法: 采用机械损伤联合三种菌对其混合感染的方法来制备大鼠的盆腔炎模型。将实验大鼠随机分为5组:正常对照组、模型组、舒康汤低剂量组(1 mL/kg)、舒康汤高剂量组(l mL/100 g)、妇科千金片组(1.5 g/kg)。造模后3周连续给药20 d,在最后一次给药的24 h后,对子宫的肿胀程度进行观察并检测每组大鼠的血浆中SOD、MDA以及IL-1β、IL-6和 TNF-α的含量。结果: 舒康汤可以明显地使造模大鼠的子宫肿胀程度减轻,并且,可以使慢性盆腔炎大鼠模型血浆中的MDA、IL-1β、IL-6和 TNF-α含量降低,SOD含量提高。结论: 舒康汤对慢性盆腔炎的治疗作用可能与对氧自由基损伤以及炎症细胞因子的抑制有关。

关键词: 舒康汤, 慢性盆腔炎, 实验研究

Abstract: AIM: To observe the effect of Shukang soup on Chronic pelvic inflammatory disease and investigate its possible mechanism.METHODS: The rat model was made by three kinds of bacteria mixed infection and mechanical damage. The rats were randomly divided into five groups: normal control group, model group, low dose group Shukang soup (1 mL/kg), high-dose group Shukang soup (1 mL/100g), Qianjinpian group (1.5 g/kg). After the last administration, Swelling of the uterus were observed and SOD, MDA and IL-1β, IL-6 and TNF-α were tested.RESULTS: Shukang soup can obviously reduce the degree of swelling of the uterus modeling rats, and MDA, IL-1β, IL-6 and TNF-α were reduced, SOD was increased.CONCLUSION: Shukang soup have a therapeutic effect on chronic pelvic inflammatory disease, this effect may be due to the inhibition of Oxygen free radical damage and inflammatory cytokines.

Key words: Shukang soup, chronic pelvic inflammatory disease, experimental study

中图分类号:

R965.2

吴伟平, 赖唐秀, 段志芳. 舒康汤治疗慢性盆腔炎的实验研究[J]. 中国临床药理学与治疗学, 2015, 20(5): 510-513.

WU Wei-ping, LAI Tang-xiu, DUAN Zhi-fang. Experimental study on Shukang Soup in treatment of chronic pelvic inflammatory disease[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2015, 20(5): 510-513.

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