脱发实验模型及其药物治疗学现状

摘要/Abstract

摘要：

脱发是一种以毛发缺失为特征的疾病，其病理生理机制及毛发再生治疗是当前研究的焦点问题。脱发实验模型的成功复制对脱发病理机制和药物治疗学研究起到关键的推动作用。本文就国内外已经建立的体内脱发动物模型，体外脱发器官模型及其实验治疗学进展作系统综述，方便研究者根据需要选择合适的模型开展实验。

关键词: 脱发, 实验模型, 自发性脱发, 药物诱导性脱发, 全厚皮肤移植诱导脱发, 药物治疗

Abstract:

Alopecia is a kind of disease characterized by loss of hair. Pathophysiological mechanism of alopecia and its hair regeneration therapy is the pressing issues of current study. The successful replication of Alopecia experimental model plays a key role in promoting the study of pathological mechanism and pharmacotherapeutics. This review systematically describes the progress in alopecia animal model and in vitro organ model, which have been established at home and abroad. Based upon the aforementioned experimental models, some relevant applications in experimental therapeutics are simultaneously enumerated. Hopefully all these information facilitate the researchers according to the need to select the appropriate model to carry out the experiment.

Key words: alopecia, experimental model, spontaneous alopecia, drug-induced alopecia, full thickness skin graft induced alopecia, pharmacotherapeutics

中图分类号:

R965.1

金建波，章建华. 脱发实验模型及其药物治疗学现状[J]. 中国临床药理学与治疗学, 2017, 22(1): 115-120.

JIN Jianbo, ZHANG Jianhua . Research progress of alopecia experimental model and its pharmacotherapeutics[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2017, 22(1): 115-120.

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