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中国临床药理学与治疗学 ›› 2017, Vol. 22 ›› Issue (12): 1426-1431.

• 医院药学之窗 • 上一篇    下一篇

药物相互作用对华法林抗凝强度的影响分析

杨 瑞1,许海沙1,张赞玲1,屈 健2,李 娟1,彭世琪1,代宇鑫1,屈 强1   

  1. 1 中南大学湘雅医院药学部,长沙 410008,湖南;2 中南大学湘雅二医院药学部,长沙 410011,湖南
  • 收稿日期:2017-06-08 修回日期:2017-11-15 出版日期:2017-12-26 发布日期:2018-01-02
  • 通讯作者: 屈强,男,博士,助理研究员,研究方向:药物基因组学。 Tel: 0731-84327460 E-mail: quqiang@csu.edu.cn
  • 作者简介:杨瑞,女,硕士研究生,研究方向:临床药学。 Tel: 0731-84327460 E-mail: yangrui198807@163.com
  • 基金资助:

    国家自然科学基金资助(81503166, 81603208);中南大学湘雅医院青年基金(2014Q08)

Effect of drug interaction on anticoagulant strength of warfarin

YANG Rui 1, XU Haisha 1, ZHANG Zanling 1, QU Jian 2, LI Juan 1, PENG Shiqi 1, DAI Yuxin 1, QU Qiang 1   

  1. 1 Department of Pharmacy, Xiangya Hospital, Central South Univesty, Changsha 410008, Hunan, China; 2 Department of Pharmacy, the Second Xiangya Hospital, Central South Univesty, Changsha 410011, Hunan, China
  • Received:2017-06-08 Revised:2017-11-15 Online:2017-12-26 Published:2018-01-02

摘要:

目的:通过对本院华法林的使用情况进行调查分析,为临床合理应用提供参考。方法: 采用回顾性分析法,应用临床药师工作平台,调取本院2016年11月至2017年2月使用华法林医嘱。对患者一般情况、疾病诊断、华法林用药情况、联合用药物情况及国际标准化比值(INR)等进行统计分析。 结果: 本次调查共纳入200例患者,其中男性占53%,女性占47%,平均年龄(55.28±13.56)岁。住院期间使用华法林,平均INR值达目标范围的比率仅为21%,平均用药剂量为(2.62±0.60)mg。分析INR值<2的患者中,合并有1种以上降低INR值药物,占66.92%,在INR值>3的患者中,合并有1种以上增高INR值药物,占80%,表明在INR值未达标患者中合并有影响华法林疗效的药物所占的比率很高。结论:华法林抗凝强度达目标值的比率很低,在未达标患者中药物相互作用影响比例大,临床药师应利用专业优势,进行个体化指导用药,保障患者用药安全。

关键词: 华法林, 药物相互作用, 抗凝强度, 合理用药

Abstract:

AIM: To provide rational evidence for the administration of warfarin in clinic by investigating the utilization of warfarin in our hospital.  METHODS: By retrospective analysis, the prescription of warfarin in our hospital was obtained from November 2016 to February 2017 from the system for clinical pharmacist. The general situation of the inpatient, the diagnosis of disease, the use of warfarin, and the combination of drugs and the number of International Normalized Ratio (INR) were statistically and descriptively analyzed. RESULTS:In this investigation, 200 patients were included, of whom 53% were males and 47% were females with an average age of (55.28±13.56) years. Only 21% of the average INR values reached the predicted range (2<INR<3) during hospitalization and the average dose of warfarin was (2.62±0.60) mg. In patients with INR<2, there were 66.92% of patients combined with more than one kind of drugs, which decreased the effect of warfarin. In patients with INR>3, there were 80% of patients combined with more than one kind of drugs, which increased the effect of warfarin. CONCLUSION:The rate of warfarin compliance is low and the warfarin-drug interactions exert a great influence on the patients whose INR value did not reach the predicted range. Thus, to keep the drug safety of patients, more attention should be paid on drug interactions and direct personalized medicine using professional knowledge of pharmacy.

Key words: warfarin, drug interaction, anticoagulant strength, rational administration of drugs

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