CYP2E1调控酒精性肝病发病机制的研究进展

中国临床药理学与治疗学 ›› 2017, Vol. 22 ›› Issue (2): 198-203.

CYP2E1调控酒精性肝病发病机制的研究进展

陈丹^1，2，林秀贤^1，2，陈尧^1，2

¹中南大学湘雅医院临床药理研究所， ²中南大学临床药理研究所，湖南省遗传药理学重点实验室，长沙 410000，湖南

收稿日期:2016-07-04 修回日期:2016-09-23 出版日期:2017-02-26 发布日期:2017-03-02
通讯作者: 陈尧，男，博士，副研究员，硕士生导师，研究方向：药物基因组学、临床药理学。 Tel：0731-84805380 E-mail:cbohua@163.com
作者简介:陈丹，女，硕士，研究方向：药物基因组学、临床药理学。 Tel：0731-84805380 E-mail:chendanjiyi@163.com
基金资助:
国家自然科学基金项目（81302850）；长沙市科技计划项目（kq1602014）；中南大学中央高校基本科研业务费专项基金资助（2016zzts512）

Research on the progress of alcoholic liver disease pathogenesis related to CYP2E1

CHEN Dan^1,2, LIN Xiuxian ^1,2, CHEN Yao^1,2

¹Department of Clinical Pharmacology, Xiangya Hospital, Central South University, ² Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics,Changsha 410000, Hunan, China

Received:2016-07-04 Revised:2016-09-23 Online:2017-02-26 Published:2017-03-02

摘要/Abstract

摘要：

酒精性肝病（alcoholic liver disease，ALD）是长期饮酒或数周内大量酗酒引起的肝脏损伤，细胞色素P450 2E1（CYP2E1）是参与酒精代谢的主要酶类之一，在酒精毒性代谢和ALD致病过程中起着重要作用。CYP2E1体内表达量、活性水平、代谢酒精过程中产生的氧自由基量以及毒性代谢产物能够通过不同方式影响ALD的患病风险以及病程发展，其影响机制与多条信号通路有关。各信号通路间交互错杂，相互作用，共同调控机体的自我保护功能和ALD的形成及发展。本文将归纳总结CYP2E1调控ALD的形成及发展的保护和损伤机制等方面相关信号通路的研究进展，为今后ALD的防治研究提供帮助。

关键词: 酒精性肝病（ALD）, CYP2E1, Wnt-β-catenin, JNK-MAPK/NF-κB, TGF-β-Smads

Abstract:

Alcoholic liver disease (ALD) is a kind of liver damage caused by long-term drink or heavy drink by a couple of weeks. Cytochrome P450 2E1 (CYP2E1), as a main enzyme metabolizing enzyme of alcohol, plays an important role in the toxic metabolism of alcohol and the occurrence and development of ALD. The expression of CYP2E1 in vivo, the activity of CYP2E1 and free oxygen radicals and toxic metabolites produced during the metabolism of alcohol by CYP2E1 can affect the process and development of ALD in different ways. The regulation mechanisms related to CYP2E1 is involved with multiples of pathogenic molecules, pathogenesis and signaling pathways. The interplay and reciprocal action between signaling pathways could have an influence on self-protection and the occurrence and development of ALD. This review mainly summarizes the research progresses of signaling pathways both in protective and injury mechanisms that regulate the progress of ALD through CYP2E1. Our effort could provide help for the prevention and treatment of ALD in future.

Key words: alcoholic liver disease, CYP2E1, Wnt - beta - catenin, JNK-MAPK/NF-κB, TGF-β-Smads

中图分类号:

R969
R968

陈丹，林秀贤，陈尧. CYP2E1调控酒精性肝病发病机制的研究进展[J]. 中国临床药理学与治疗学, 2017, 22(2): 198-203.

CHEN Dan, LIN Xiuxian, CHEN Yao. Research on the progress of alcoholic liver disease pathogenesis related to CYP2E1[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2017, 22(2): 198-203.

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