盐酸帕罗西汀联合丹栀逍遥丸治疗抑郁症伴焦虑的临床对照研究

中国临床药理学与治疗学 ›› 2017, Vol. 22 ›› Issue (3): 321-325.

盐酸帕罗西汀联合丹栀逍遥丸治疗抑郁症伴焦虑的临床对照研究

徐道祥，史惠敏，林小东

温州市第七人民医院临床心理科，温州 325005，浙江

收稿日期:2016-12-15 修回日期:2017-01-11 出版日期:2017-03-26 发布日期:2017-03-29
作者简介:徐道祥，男，本科，副主任医师，研究方向：抑郁症伴焦虑患者的治疗。 Tel：13587872081 E-mail：shaohongh0414@163.com
基金资助:
温州市医药卫生科研项目（2014B16）

Clinical effect of paroxetine hydrochloride combined with Danzhi xiaoyao pills in the treatment of depression associated with anxiety

XU Daoxiang, SHI Huimin, LIN Xiaodong

Department of Psychology, the Seventh People's Hospital, Wenzhou 325005, Zhejiang, China

Received:2016-12-15 Revised:2017-01-11 Online:2017-03-26 Published:2017-03-29

摘要/Abstract

摘要：

目的:探讨盐酸帕罗西汀联合丹栀逍遥丸治疗抑郁症伴焦虑的临床效果。方法: 选取2014年3月至2016年3月在本院住院治疗的抑郁症伴焦虑患者160例作为研究对象，随机分为实验组和对照组，各80例，实验组给予盐酸帕罗西汀（20 mg/次，1次/d，根据病情逐渐以每周增加10 mg为阶梯递增，治疗剂量范围为20～60 mg/d）和丹栀逍遥丸（口服，6～9 g/次，2次/d）治疗，对照组仅给予盐酸帕罗西汀，两组连续治疗8周，对比分析两组患者治疗效果、HAMA评分、HAMD评分、CGI评分和不良反应。结果: 实验组临床总有效率为92.5%，明显高于对照组的81.2%，差异有统计学意义（P<0.05），两组患者复发率差异无统计学意义（P>0.05）；两组患者治疗前HAMA、HAMD评分差异无统计学意义（P>0.05），治疗2周、4周、8周后，实验组HAMA、HAMD评分明显低于对照组，差异均有统计学意义（P<0.05）；两组患者治疗前CGI评分结果差异无统计学意义（P>0.05），治疗2周、4周、8周后CGI评分差异有统计学意义（P<0.05）；治疗8周期间，实验组嗜睡10例（12.5%），明显低于对照组的24例（30.0%），差异有统计学意义（P<0.05），恶心、口干、便秘、多汗、乏力、心悸、头痛等项目比较，差异无统计学意义（P>0.05）。结论:盐酸帕罗西汀联合丹栀逍遥丸治疗抑郁症伴焦虑的临床效果良好，患者对药物的耐受性好，具有较高的临床价值。

关键词: 盐酸帕罗西汀, 丹栀逍遥丸, 抑郁症伴焦虑, 临床效果

Abstract:

AIM: To investigate the clinical effect of paroxetine hydrochloride combined with Danzhi xiaoyao pills in the treatment of depression associated with anxiety. METHODS: Between March 2014 and March 2016, 160 patients with depression and anxiety in our hospital were selected as study subjects, randomly divided into experimental group and control group, each of 80 cases, the experimental group was given Pa Rossi Dean hydrochloride (20 mg/times, 1 times/d, according to the state of the disease gradually increased by 10mg per week to step by step, the therapeutic dose range of 20-60 mg/d) and Danzhi xiaoyao pills (oral, 6-9 g/time, 2 times/d) treatment, 8 weeks of continuous treatment, treatment effect, HAMA score, HAMD score, CGI score and adverse reactions of two groups were compared. RESULTS: The clinical total effective rate of the experimental group was 92.5%, significantly higher than that of 81.2% of the control group, the difference was statistically significant (P<0.05), there was no significant difference in recurrence rate between the two groups (P>0.05); 2 weeks, 4 weeks and 8 weeks after the treatment, HAMA, HAMD scores of the experimental group were significantly lower than the control group, the differences were statistically significant (P<0.05); There was no significant difference between the two groups before treatment (P>0.05), there was significant difference in CGI score 2 weeks, 4 weeks and 8 weeks after treatment (P<0.05); During the 8 week treatment, 24 patients (12.5%) in the experimental group were significantly lower than those in the control group (30%), and the difference was statistically significant (P<0.05), no significant difference was found between nausea, dry mouth, constipation, sweating, fatigue, palpitation, headache and other items (P>0.05). CONCLUSION: Clinical effect of paroxetine hydrochloride combined with Danzhi xiaoyao pills in the treatment of depression associated with anxiety show good tolerance to drugs, which is of high clinical value.

Key words: Paroxetine hydrochloride, Danzhi xiaoyao pills, depression associated with anxiety, clinical effect

中图分类号:

R749

徐道祥，史惠敏，林小东. 盐酸帕罗西汀联合丹栀逍遥丸治疗抑郁症伴焦虑的临床对照研究[J]. 中国临床药理学与治疗学, 2017, 22(3): 321-325.

XU Daoxiang, SHI Huimin, LIN Xiaodong. Clinical effect of paroxetine hydrochloride combined with Danzhi xiaoyao pills in the treatment of depression associated with anxiety[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2017, 22(3): 321-325.

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