关键词: 非心源性急性脑梗死, 血清B型利钠肽前体, 血压变异性, 预后

Abstract:

AIM: To discuss the application of serum B type natriuretic peptide precursor and blood pressure variability in patients with non-cardiogenic ischemic stroke. METHODS:Eighty-six patients with non cardiogenic acute cerebral infarction were selected as the case group, and 40 healthy volunteers were selected as control group. The serum levels of pro-BNP and blood pressure variability were compared between the two groups. RESULTS:The level of serum pro-BNP in the case group was (984.63±148.67) ng/L, which was significantly higher than that of the control group（138.44±30.75）ng/L (P<0.01). The 24 h systolic pressure variation coefficient (24 h SBPCV), 24 h diastolic pressure variation coefficient(24 h DBPCV), 24 h systolic pressure standard deviation(24 h SBPSD), 24 h diastolic pressure standard deviation(24 h DBPSD) and comparison of blood pressure variability coefficients independent of mean(VIM) between the two groups were statistically significant (P<0.01). Serum pro-BNP was positively correlated with 24 h SBPCV, 24 h DBPCV, 24 h SBPSD, 24 h DBPSD. The serum pro-BNP level in the death group was （1 326.36±156.85）ng/L, which was significantly higher than that of the survival group （910.28±118.47）ng/L (P<0.01). The difference of 24 h SBPCV, 24 h DBPCV, 24 h SBPSD, 24 h DBPSD,VIM between the two groups was statistically significant (P<0.05). CONCLUSION:The level of serum pro-BNP and the variation of blood pressure are closely related to the prognosis of patients with non- cardiogenic acute cerebral infarction.

Key words: non-cardiogenic ischemic stroke, serum B type natriuretic peptide, blood pressure variability, prognosis