失重环境药物代谢动力学研究

中国临床药理学与治疗学 ›› 2017, Vol. 22 ›› Issue (6): 709-712.

失重环境药物代谢动力学研究

王小青^1,2，周杰兆²，程泽能¹，姜德建²

¹中南大学药学院药剂学系，湖南省药物制剂优化与早期临床评价工程技术研究中心，长沙 410013，湖南；²湖南省药物安全评价研究中心，新药药效与安全性评价湖南省重点实验室，长沙 410331，湖南

收稿日期:2016-10-20 修回日期:2017-01-04 出版日期:2017-06-26 发布日期:2017-06-26
通讯作者: 姜德建，男，研究员，研究方向：新药研发与评价。 E-mail: Jiangdejian@hnse.org
作者简介:王小青，女，在读博士，研究方向：药代动力学。 E-mail:wangxiaoqing@hnse.org
基金资助:
湖南省科技计划（2015DK3010）；湖湘青年创新人才基金（2014）；人因工程国家重点实验室开放课题（SYFD150051808K）

Research on pharmacokinetics in weightless environment

WANG Xiaoqing^1,2, ZHOU Jiezhao², CHENG Zeneng ¹, JIANG Dejian ²

¹ Pharmacy Department of Central South University School of Medicine，Engineering Technology Research Center for Optimization and Early Clinical Evaluation of Pharmaceutical Preparation in Hunan Province，Changsha 410013, Hunan, China; ²Hunan Center for Safety Evaluation and Research of Drugs, Hunan Key Laboratory for Pharmacodynamics and Safety Evaluation of new drugs, Changsha 410013, Hunan, China

Received:2016-10-20 Revised:2017-01-04 Online:2017-06-26 Published:2017-06-26

摘要/Abstract

摘要：

航天药代动力学是航天医学的重要组成部分。航天失重引起的机体生理、生化功能变化进而导致药物的代谢动力学特征发生改变，是影响航天用药的关键因素之一。本文从失重的实验模型，失重对药物吸收、分布、代谢和排泄各环节的影响以及失重条件下药动学研究的影响因素进行综述，为航天药代动力学研究提供一定参考。

关键词: 失重, 药物代谢动力学

Abstract:

Space pharmacokinetics is an important part of aerospace medicine. The change of pharmacokinetics caused by the change of physiological and biochemical function of weightlessness in space, is one of the key factors influencing the use of medicine. This article reviewed the research progress including experimental models, the effects on the absorption, distribution, metabolism and excretion of drugs, and the influencing factors of pharmacokinetics of weightlessness, which may provide some reference for space pharmacokinetics.

Key words: weightless, pharmacokinetics

中图分类号:

R969.1

王小青，周杰兆，程泽能，姜德建. 失重环境药物代谢动力学研究[J]. 中国临床药理学与治疗学, 2017, 22(6): 709-712.

WANG Xiaoqing, ZHOU Jiezhao, CHENG Zeneng, JIANG Dejian. Research on pharmacokinetics in weightless environment[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2017, 22(6): 709-712.

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