关键词: 肠宁方灌肠, 美沙拉嗪, 溃疡性直肠炎, 炎症因子, 凝血功能

Abstract:

AIM: To study the effect of Changningfang enema combined with mesalazine on inflammatory factors and coagulation function in patients with ulcerative proctitis (UP), and to explore the clinical value of combined therapy.  METHODS: One hundred and seventy four patients with UP were enrolled in this study from September 2014 to July 2016. The patients were divided into observation group and control group by random number table method. The patients in the control group were treated with mesalazine, and the patients in the observation group were treated with enteric-enema according to the control group. Inflammatory factors, coagulation functions and clinical efficacy of the two groups were detected before and after treatment. RESULTS:After treatment, TNF-α, IL-8 and HMBG1 levels were significantly decreased in both groups,while IL-4 and IL-10 were significantly increased (P<0.05), and TNF-α, IL-4 and IL-10 were significantly higher than those in the control group (P<0.05). The levels of D-dimer, PT, APTT, FIB and PLT in the two groups were significantly lower than those in the control group (P<0.05). The effective rate of the observation group was 87.36%. The effective rate of treatment was 66.67%, the difference was statistically significant (P<0.05). CONCLUSION:Intestinal enema combined with mesalazine treatment of UP can significantly inhibit the symptoms of patients with inflammation, improve its blood hypercoagulable state,and the clinical effect is satisfactory.

Key words: Changningfang enema, mesalazine, ulcerative proctitis, inflammatory factors, coagulation function