关键词: 参附注射液, 心肺复苏, 心肌功能, 肝肾功能, 保护

Abstract:

AIM: To investigate the protective effect of Shenfu injection on cardiac muscle and liver and renal function in patients with cardiopulmonary resuscitation.  METHODS: Sixty cases of cardiopulmonary resuscitation were divided into study group and control group (n=30). The control group was given conventional symptomatic treatment, on the basis of which, the study group was given the Shenfu injection in the meantime of cardiopulmonary resuscitation. Cardiac function indexes (CK-MB, cTnI), liver and kidney function indexes (ALT, Cr), the levels of inflammatory factors (hs-CRP, TNF-α) were compared 0 hour, 24 hours and 48 hours after the resuscitation.RESULTS:After the resuscitation, levels of CK-MB, cTnI, ALT, Cr, hs-CRP, TNF-α were significantly increased in both groups (P<0.05). While the increase of these parameters in the study group was significantly lower than those in the control group at 24 hours and 48 hours after cardiopulmonary resuscitation. The difference was statistically significant (P<0.05). The mortality rate (36.67%) of the study group was significantly lower than that of the control group (70%) (χ2=5.406, P<0.05). CONCLUSION:Shenfu injection exerts protective effect on cardiac muscle and liver and renal function in patients with acute cardiopulmonary resuscitation, and can significantly improve the prognosis of patients with acute cardiopulmonary resuscitation.

Key words: Shenfu injection, cardiopulmonary resuscitation, cardiac function, liver and kidney function, protection