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中国临床药理学与治疗学 ›› 2017, Vol. 22 ›› Issue (8): 852-858.

• 基础研究 • 上一篇    下一篇

复方鹿角乳痛宁胶囊与原基础方的药效学对比研究

冷晓微1,Rita1,李 敏1,张 桐1,任立群1,范志民1,2   

  1. 1吉林大学药学院,长春 130021,吉林;2吉林大学第一医院乳腺外科,长春 130021,吉林
  • 收稿日期:2017-03-07 修回日期:2017-05-10 出版日期:2017-08-26 发布日期:2017-08-18
  • 通讯作者: 范志民,男,教授,博士生导师,研究方向为乳腺癌的差异表达蛋白质分析和乳腺癌的早期诊断、治疗,生存分析和预后因素研究。 E-mail: fanzhimin780213@126.com
  • 作者简介:冷晓微,女,硕士,研究方向为心血管分子药理学。 E-mail: 511093958@qq.com
  • 基金资助:

    长春市科技计划项目(14KG048)

Comparison of pharmacodynamics of Fufang lujiao rutongning capsule and its original formula

LENG Xiaowei 1, Rita 1, LI Min 1, ZHANG Tong 1, REN Liqun 1, FAN Zhimin 2   

  1. 1 School of Pharmacy, Jilin University, Changchun 130021, Jilin, China; 2 Department of Breast Surgery, the First Hospital of Jilin University, Changchun 130021, Jilin, China
  • Received:2017-03-07 Revised:2017-05-10 Online:2017-08-26 Published:2017-08-18

摘要:

目的: 对比复方鹿角乳痛宁胶囊经配伍改进后与基础方乳痛宁胶囊对大鼠乳腺增生的治疗作用及镇痛作用。方法: 肌肉注射雌二醇及黄体酮复制大鼠乳腺增生疾病模型,测定大鼠血清中性激素及乳腺组织中性激素受体蛋白表达水平,对比复方鹿角乳痛宁胶囊和乳痛宁胶囊对乳腺增生的治疗作用;腹腔注射冰醋酸复制小鼠疼痛模型,比较潜伏时间、扭体次数和镇痛率,评价复方鹿角乳痛宁胶囊和乳痛宁的镇痛作用。结果: 乳痛宁胶囊改进前后对大鼠乳腺增生均有明显的改善作用,且复方鹿角乳痛宁胶囊配伍改进后的疗效和镇痛作用明显优于乳痛宁胶囊。结论: 配伍改进后复方鹿角乳痛宁胶囊治疗乳腺增生、镇痛作用较原基础方乳痛宁胶囊有明显提高。

关键词: 复方鹿角乳痛宁胶囊, 乳痛宁胶囊, 乳腺增生, 镇痛

Abstract:

AIM: To compare the therapeutic and analgesic effect of improved Fufang lujiao rutongning capsule and its original formula on hyperplasia of mammary glands in rats.  METHODS: The model of mammary glands hyperplasia was induced by intramuscular injection of estradiol and progesterone so as to evaluate the action receptors in breast issues and the serum levels of hormone and to compare the therapeutic effect of both formulas. In the analgesic experiment, glacial acetic acid was used to induce writhing to compare the time of latency, number of writhing and of analgesic rate of the two formulas. RESULTS: Both formulas of Rutongning capsule could alleviate the breast hyperplasia, while the improved formula presented better therapeutic and analgesic effect. CONCLUSION: Fufang lujiao rutongning capsule is better than Rutongning capsule for controlling hyperplasia pain.

Key words: Fufang lujiao rutongning capsule, Rutongning capsule, hyperplasia of mammary glands, analgesia

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