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中国临床药理学与治疗学 ›› 2017, Vol. 22 ›› Issue (8): 910-916.

• 定量药理学 • 上一篇    下一篇

瘦素及其受体基因多态性与高血压相关性的Meta分析

张晓宇,方正美,姚应水   

  1. 皖南医学院公共卫生学院,芜湖 241002,安徽
  • 收稿日期:2017-01-24 修回日期:2017-03-03 出版日期:2017-08-26 发布日期:2017-08-18
  • 通讯作者: 姚应水,男,博士,教授,硕士研究生导师,研究方向:慢性病流行病学。 Tel:13053269969 E-mail:yingshuiyao@163.com
  • 作者简介:张晓宇,男,硕士研究生,研究方向:慢性病流行病学。 Tel:18133418010 E-mail:378577855@qq.com
  • 基金资助:

    国家自然科学基金资助项目(81541071;81072367)

Association of leptin and leptin receptor gene polymorphisms with hypertension: a Meta-analysis

ZHANG Xiaoyu, FANG Zhengmei, YAO Yingshui   

  1. School of Public Health, Wannan Medical College, Wuhu 241002, Anhui, China
  • Received:2017-01-24 Revised:2017-03-03 Online:2017-08-26 Published:2017-08-18

摘要:

目的:系统评价瘦素(LEP)及其受体(LEPR)基因多态性与高血压的相关性。方法: 通过中国知网(CNKI)、维普、万方数据库、Pubmed、EMBASE等中外数据库,查全瘦素及其受体基因与高血压相关文献,按照Newcastle-Ottawa Scale质量评价标准对文献进行质量评价,使用STATA11.0对数据进行分析。结果:纳入21篇文献,共7 832例研究对象,病例组4 736例,对照组3 096例。Meta分析结果,LEP基因II/I在隐性和加性模型下与高血压相关(隐性模型:OR=2.16,95%CI=1.08-4.31,P=0.029,加性模型:OR=2.27,95%CI=1.08-4.79,P=0.031);LEPR基因Gln223Arg在显性和等位基因模型下与高血压相关(显性模型:OR=1.55,95%CI=1.14-2.11,P=0.005,等位基因:OR=1.36,95%CI=1.09-1.71,P=0.007);Lys109Arg与高血压无显著相关(显性模型OR=0.87,95%CI=0.67-1.14,P=0.307,隐性模型:OR=0.91,95%CI=0.70-1.20,P=0.099,加性模型:OR=0.92,95%CI=0.70-1.21,P=0.071,等位基因模型:OR=1.04,95%CI=0.80-1.35,P=0.830)。 结论:LEP基因II/I与高血压相关,提示携带I/I基因型是高血压发病危险因素。LEPR基因Gln223Arg与高血压相关,且携带AA+AG基因型、A等位基因是高血压发病的危险因素;Lys109Arg与高血压无显著相关。

关键词: 高血压, 瘦素, 瘦素受体, 基因多态性, Meta分析

Abstract:

AIM: To evaluate the association between leptin gene and leptin receptor gene polymorphisms with hypertension.  METHODS: CNKI, Wanfang database, Chongqing VIP network, Pubmed database and EMBASE database were researched. The data on the relationship between leptin/its receptor gene and hypertension were extracted and evaluated by software STATA11.0. RESULTS: Twenty-one studies involving 4 736 patients and 3 096 healthy people were included. The meta-analysis showed the II/I polymorphism of LEP gene was associated with hypertension in recessive genetic model and additive genetic model (recessive genetic model: OR=2.16, 95%CI=1.08-4.31, P=0.029, additive genetic model: OR=2.27, 95%CI=1.08-4.79, P=0.031); the Gln223Arg polymorphism of LEPR gene was associated with hypertension in dominant model and allelic model (dominant model: OR=1.55, 95%CI=1.14-2.11, P=0.005; allelic model: OR=1.36,95%CI=1.09-1.71, P=0.007). No statistically significant correlation was found between the Lys109Arg polymorphism of LEPR gene and hypertension (dominant model: OR=0.87, 95%CI=0.67-1.14, P=0.307, recessive genetic model: OR=0.91, 95%CI=0.70-1.20, P=0.099, additive genetic model: OR=0.92, 95%CI=0.70-1.21, P=0.071, allelic model: OR=1.04, 95%CI=0.80-1.35, P=0.830). CONCLUSION: There is no significant correlation between Lys109Arg polymorphism of LEPR gene and hypertension, but the II/I polymorphism of LEP gene and Gln223Arg polymorphism of LEPR gene are associated with hypertension.

Key words: hypertension, leptin, leptin receptor, gene polymorphism, Meta-analysis

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