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中国临床药理学与治疗学 ›› 2017, Vol. 22 ›› Issue (8): 948-954.

• 综述与讲座 • 上一篇    下一篇

表面修饰白蛋白纳米粒在肿瘤靶向治疗中的研究进展

许丽华1,徐肖阳1,徐骏军2,俞文英1   

  1. 1 浙江省医学科学院,药物研究所,杭州 310013,浙江; 2 浙江大学医学院附属第二医院,杭州 310052,浙江
  • 收稿日期:2017-02-13 修回日期:2017-03-14 出版日期:2017-08-26 发布日期:2017-08-18
  • 通讯作者: 俞文英,女,硕士,助理研究员,研究方向:靶向缓控释药物制剂的研究与开发。 Tel:0571-88215628 E-mail:zjyuwenying@163.com
  • 作者简介:许丽华,女,在读硕士研究生,研究方向:靶向制剂的研究。 Tel:0571-88215628 E-mail:978456203@qq.com
  • 基金资助:

    浙江省中医药科技计划项目(2016ZA130)

Research progress of surface modified albumin nanoparticles in tumor targeting therapy

XU Lihua 1, XU Xiaoyang 1, XU Junjun 2, YU Wenying 1   

  1. 1 Institute of Medical, Zhejiang Academy of Medical Sciences, Hangzhou 310013, Zhejiang, China; 2 The Second Affiliated Hospital of Zhejiang University, Hangzhou 310052, Zhejiang, China
  • Received:2017-02-13 Revised:2017-03-14 Online:2017-08-26 Published:2017-08-18

摘要:

目前临床肿瘤治疗中的药物多为非选择性药物,在抑制肿瘤细胞增殖的同时,也会对正常组织器官产生显著的毒副作用,因此提高药物的肿瘤选择性,减少其在非靶向部位的聚集是提高抗肿瘤药物疗效的关键。白蛋白纳米粒作为药物载体,具有突出的生物学特性,目前已被应用于各种靶向制剂。本文对白蛋白纳米粒在肿瘤中的聚集特性,以及其经精氨酸-甘氨酸-天冬氨酸短肽(RGD肽)、叶酸、单克隆抗体、透明质酸、转铁蛋白等靶向材料修饰后在肿瘤靶向治疗中的研究和临床应用做了最新的概述,旨在为开发安全、有效的肿瘤靶向制剂提供参考。

关键词: 白蛋白纳米粒, 靶向修饰, 肿瘤治疗, 应用

Abstract:

At present, most drugs for clinical cancer therapy are non-selective, with the inhibition of tumor cell proliferation, they also have significant side effects on normal tissues, thereby improving the tumor-selective capacity, reducing their gathering in non-targeted areas are the keys to enhance the effectiveness of anti-cancer drugs. As drug carriers, albumin nanoparticles exhibit various outstanding biological properties, and now have been used in targeted delivery systems. The paper reviews the albumin's tumor aggregation features, the latest researches in the targeted therapy of tumor and clinical applications when they are modified with RGD peptides, monoclonal antibodies, folic acid, hyaluronic acid, transferrin and other targeted material,in order to provide advices for developing safe and effective tumor targeting drugs.

Key words: albumin nanoparticles, targeted modification, tumor therapy, applications

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