月经周期阶段性中药方剂在子宫内膜异位不孕症患者中的应用及对血清免疫因子的影响

doi:10.12092/j.issn.1009-2501.2018.06.012

中国临床药理学与治疗学 ›› 2018, Vol. 23 ›› Issue (6): 672-677.doi: 10.12092/j.issn.1009-2501.2018.06.012

月经周期阶段性中药方剂在子宫内膜异位不孕症患者中的应用及对血清免疫因子的影响

高涛，方晓红，马景，褚蕴，陈碧霞

杭州市中医院，杭州 310007，浙江

收稿日期:2018-03-13 修回日期:2018-04-02 出版日期:2018-06-26 发布日期:2018-06-19
作者简介:高涛，男，博士研究生，副主任中医师，研究方向：中西医诊治妇科常见病、疑难病研究。 E-mail:eyes-on-you@163.com
基金资助:
浙江省中医药科技计划（2018ZB087）

Effects of menstrual cycle periodic Chinese medicine prescription on endometriosis infertility patients

GAO Tao, FANG Xiaohong, MA Jing, CHU Yun, CHEN Bixia

Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou 310007, Zhejiang, China

Received:2018-03-13 Revised:2018-04-02 Online:2018-06-26 Published:2018-06-19

摘要/Abstract

摘要：

目的：分析月经周期阶段性中药方剂在子宫内膜异位（EMs）不孕症患者中的应用效果，为EMs不孕症患者的临床治疗提供参考。方法：选取2014年3月至2016年7月在杭州市中医院诊断且符合纳入标准的74例EMs不孕症患者为研究对象，采用随机数字表法将其分为观察组和对照组。对照组患者采用地屈孕酮片治疗，观察组患者在对照组基础上加用月经周期阶段性中药方剂治疗，比较两组患者的临床疗效、免疫功能、卵巢功能及妊娠结局。结果：观察组患者的临床治疗总有效率显著高于对照组（P<0.05）。治疗前，两组患者的CD+3、CD+4、CD+4/CD+8、自然杀伤细胞（NK）、雌二醇（E2）及抗苗勒管激素(AMH)水平比较均无统计学差异（P>0.05）；治疗后，两组患者的CD+3、CD+4、CD+4/CD+8、NK、E2及AMH水平均显著高于治疗前（P<0.05），且观察组高于对照组（P<0.05）。治疗前，两组患者的促黄体生成素（LH）和促卵泡生成激素（FSH）水平比较均无统计学差异（P>0.05）；治疗后，两组患者的LH及FSH水平均显著低于治疗前（P<0.05），且观察组低于对照组（P<0.05）。观察组患者的妊娠成功率显著高于对照组（P<0.05）。结论：月经周期阶段性中药方剂可调节EMs不孕患者的免疫功能，改善患者卵巢功能，提高患者妊娠率。

关键词: 月经周期, 阶段性, 中药方剂, 子宫内膜异位不孕症

Abstract:

AIM: To investigate the application of menstrual cycle periodic Chinese medicine prescription in endometriosis (EMs) infertility patients, and to provide a reference for the clinical treatment of EMs infertility patients. METHODS: A total of 74 infertility patients with EMs from March 2014 to July 2016 who met the inclusion criteria in our hospital were selected, and were randomly divided into observation group (n=37) and control group (n=37) according to the random number table method. The control group was treated with dydrogesterone tablets, while the observation group was treated with menstrual cycle periodic Chinese medicine prescription based on the control group. The clinical effect, immune function, ovarian function and pregnancy outcome were compared between the two groups. RESULTS: The total effective rate of clinical treatment in observation group was significantly higher than that of control group (P<0.05). Before treatment, there were no significantly differences in the level of CD3⁺, CD4⁺, CD4⁺ /CD8⁺, natural kille (NK), estradiol 2 (E2) and anti-mullerian hormone (AMH) between the two groups (P>0.05). After treatment, the level of CD3⁺, CD4⁺, CD4⁺ /CD8⁺ , NK E2 and AMH were significantly better than those of before treatment (P<0.05), and the observation group was significantly better than the control group (P<0.05). Before treatment, there were no significantly differences in the level of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) between the two groups (P>0.05). After treatment, the level of LH and FSH were significantly lower than those of before treatment (P<0.05), and the observation group was significantly lower than the control group (P<0.05). The success rate of pregnancy in observation group was significantly higher than that of control group (P<0.05). CONCLUSION: The menstrual cycle periodic Chinese medicine prescription can adjust the immune function, improve the ovarian function, and increase the pregnancy rate of the EMs infertile patients.

Key words: menstrual cycle, periodic, Chinese medicine prescription, endometriosis infertility

中图分类号:

R711.71

高涛，方晓红，马景，褚蕴，陈碧霞. 月经周期阶段性中药方剂在子宫内膜异位不孕症患者中的应用及对血清免疫因子的影响[J]. 中国临床药理学与治疗学, 2018, 23(6): 672-677.

GAO Tao, FANG Xiaohong, MA Jing, CHU Yun, CHEN Bixia. Effects of menstrual cycle periodic Chinese medicine prescription on endometriosis infertility patients[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2018, 23(6): 672-677.

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月经周期阶段性中药方剂在子宫内膜异位不孕症患者中的应用及对血清免疫因子的影响

Effects of menstrual cycle periodic Chinese medicine prescription on endometriosis infertility patients

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