关键词: 比索洛尔, 丹参多酚酸盐, 冠心病, PCI, 微炎环境, 血液流变学

Abstract:

AIM: To analyze the influence of bisoprolol combined with salvianolate on the inflammatory microenvironment and hemorheology indexes of patients with coronary heart disease after percutaneous coronary intervention (PCI). METHODS: Totally 120 cases of patients with coronary heart disease treated in our hospital from July, 2015 to May, 2017 who underwent PCI were randomly divided into control group and experimental group according to computer-generated number table method, with 60 cases in each group. The patients in control group were given conventional treatment, and the patients in experimental group were administered bisoprolol combined with salvianolate on that basis. The inflammatory microenvironment and hemorheology indexes of the patients in both groups were comparatively analyzed. RESULTS:After treatment, the levels of hypersensitive C-reactive protein (hs-CRP), TNF-α, lipoprotein-associated phospholipase A2 (Lp-PLA2), soluble intercellular adhesion molecule-1 (sICAM-1), Toll-like receptors 4 (TLR4) and soluble vascular cell adhesionmolecula-1 (sVCAM-1) in experimental group were all lower than those in control group, with statistically significant (P＜0.05). The hematokrit, whole blood high shear viscosity, fibrinogen, whole blood low shear viscosity, erythrocyte aggregation index as well as plasma viscosity in experimental group were all lower than those in control group, while the erythrocyte deformation index was higher, with statistically significant (P＜0.05). Both the left ventricular end diastolic diameter and the left ventricular end systolic diameter in experimental group were lower than those in control group, whereas the left ventricular ejection fraction showed the opposite response, with statistically significant (P＜0.05). The levels of monocyte chemoattractant protein-1 (MCP-1), growth differentiation factor-15 (GDF-15) and lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) in the experimental group were all lower than those in control group, while the level of visceral adipose tissue- derived serine protease inhibitor (Vaspin) in the experimental group was higher than that of the control group, with statistically significant (P＜0.05). CONCLUSION:The combination of bisoprolol and salvianolate is conducive to improving the inflammatory microenvironment, hemorheology and cardiac function indexes of patients with coronary heart disease after PCI, and is worthy to be popularized.

Key words: bisoprolol,   salvianolate, coronary heart disease, PCI, inflammatory microenvironment, hemorheology indexes