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中国临床药理学与治疗学 ›› 2021, Vol. 26 ›› Issue (5): 504-510.doi: 10.12092/j.issn.1009-2501.2021.05.005

• 睡眠障碍诊治专栏 • 上一篇    下一篇

快眼动期睡眠行为障碍的诊断与治疗进展

袁 媛,张益萌,李 宁,詹淑琴   

  1. 首都医科大学宣武医院神经内科,北京 100053
  • 收稿日期:2020-08-13 修回日期:2020-11-10 出版日期:2021-05-26 发布日期:2021-06-02
  • 通讯作者: 詹淑琴,女,硕士,主任医师、教授,研究方向:神经变性疾病相关睡眠障碍的神经机制研究,睡眠障碍与情绪。 E-mail: shqzhan@hotmail.com
  • 作者简介:袁媛,女,本科,在读硕士研究生,研究方向:神经变性病相关睡眠障碍。 E-mail: yuany_7171@163.com
  • 基金资助:
    国家自然科学基金面上项目(81571294)

Progress in the diagnosis and treatment of rapid eye movement sleep behavior disorder

YUAN Yuan, ZHANG Yimeng, LI Ning, ZHAN Shuqin   

  1. Neurology of Xuanwu Hospital Capital Medical University, Beijing 100053, China
  • Received:2020-08-13 Revised:2020-11-10 Online:2021-05-26 Published:2021-06-02

摘要: 快眼动期睡眠行为障碍(rapid eye movement sleep behavior disorder, RBD)的特征是在快眼动睡眠期间梦境演绎和肌失迟缓。RBD与α-突触核蛋白病密切相关,包括帕金森氏病(PD),路易体痴呆(DLB)和多系统萎缩(MSA)。 许多研究已经讨论了RBD的标记物,遗传、认知、自主神经功能,及其对神经退行性疾病的预测价值。本文章回顾了近几年RBD相关早期预警标记物及治疗的相关研究进展,并讨论了未来的研究方向。

关键词: 快眼动期睡眠行为障碍, 神经退行性疾病, α-突触核蛋白, 辅助检查, 治疗

Abstract: Rapid eye movement sleep behavior disorder (RBD) is characterized by dream enactment and rapid eye movement (REM) sleep without atonia. RBD is closely related to α-synucleinopathy disease, including Parkinson's disease (PD), Lewy body dementia (DLB) and multiple system atrophy (MSA). Many studies have discussed the markers, heredity, cognition, autonomic nervous function of RBD, and the predictive value for neurodegenerative diseases. This article reviews the research progress of early markers and treatments in recent years, and discusses future research directions.

Key words: rapid eye movement sleep behavior disorder (RBD), neurodegenerative diseases, α-synuclein, auxiliary examination, treatment

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