关键词: 伏立康唑, 造血干细胞移植, 治疗药物监测, 影响因素

Abstract: AIM: To study the distribution characteristics of steady-state trough concentration (Cmin) of voriconazole in Chinese patients with hematopoietic stem cell transplantation, and to explore the factors that affect its steady-state Cmin. METHODS: A retrospective analysis of 72 patients using voriconazole, the steady-state Cmin of voriconazole in 226 serum samples were determined, and clinical data of the patients were collected. SPSS 22.0 software was used to analyze the correlation between voriconazole steady-state Cmin and covariates (gender, age, weight, white blood cell count, neutrophil count, C-reactive protein, albumin, liver and kidney function, drug interactions, etc.). RESULTS: The average Cmin of voriconazole was (1.84±0.09) μg/mL, which accounted for 84.5% of the effective blood concentration range. Age, albumin, total bilirubin, and CRP had a significant effect on the blood concentration of voriconazole. Combined use of hormones did not reduce the patient's voriconazole Cmin. It was found that there were significant differences in aminotransferase, alanine aminotransferase and direct bilirubin before and after voriconazole administration. CONCLUSION: There are many factors that affect the blood concentration of voriconazole. Blood concentration monitoring should be enhanced to improve the effectiveness of voriconazole treatment and reduce side effects of drugs.

Key words: voriconazole, hematopoietic stem cell transplantation, therapeutic drug monitoring, influencing factors