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中国临床药理学与治疗学 ›› 2023, Vol. 28 ›› Issue (3): 347-354.doi: 10.12092/j.issn.1009-2501.2023.03.014

• 综述与讲座 • 上一篇    下一篇

冻伤的病理机制及治疗研究进展

张莉1,蔺兴遥1,2,尚芸1,王强1   

  1. 1甘肃中医药大学,兰州 730000,甘肃;2敦煌医学与转化教育部重点实验室,兰州 730000,甘肃
  • 收稿日期:2022-11-11 修回日期:2022-12-09 出版日期:2023-03-26 发布日期:2023-04-19
  • 通讯作者: 蔺兴遥,男,硕士生导师,教授,研究方向:从事中医药防治重大疾病基础与应用基础研究。 E-mail: 878104134@qq.com
  • 作者简介:张莉,女,在读硕士生,研究方向:从事中西医结合防治炎症免疫性疾病研究。 E-mail: 1098282689@qq.com
  • 基金资助:
    甘肃省人才发展专项资金(40160401)

Progress on the pathological mechanism and treatment of frostbite 

ZHANG Li1, LIN Xingyao1,2, SHANG Yun1, WANG Qiang1   

  1. 1 Gansu University of TCM, Lanzhou 730000, Gansu, China; 2 The Key Laboratory of the Ministry of Education of Dunhuang Medicine and Transformation, Lanzhou 730000, Gansu, China 
  • Received:2022-11-11 Revised:2022-12-09 Online:2023-03-26 Published:2023-04-19

摘要:

冻伤是机体暴露在极端寒冷环境下而发极端天气的兴趣与日俱增,以及寒区部队军事训生的组织损伤,其病理机制复杂,目前尚未完全练、战备等任务的增多,冻伤发生率随之增高。阐明。高寒高海拔地区,户外运动者遭受损伤的据报道,在高寒地区的边防部队中,局部冻伤常风险较高,严重冻伤具有较高的致残、致死率,探成批发生,造成非战斗减员增加,严重削弱部队究冻伤的病理机制有助于确定治疗手段和时机。重度冻伤可能导致伤者截肢,甚至危目前临床治疗冻伤,以对症治疗为主,如药物治及生命。冻伤严重程度与接触面温度差、皮肤暴疗、手术治疗,疗效尚不能满足临床需求,因此寻露时间及冻伤组织面积和深度相关。近年来,冻求更为高效的药品或治疗手段具有重要的意义。伤的治疗及基础研究均有长足的进步。本文综本文综述了近年来冻伤病理生理机制、临床治述了近年来冻伤病理生理、治疗及细胞和分子途径研究等方面的相关研究进径研究等方面的研究进展,以期为未来研究方向及临床治疗提供新的思路。

关键词: 冻伤, 病理机制, 治疗, 研究进展

Abstract:

Frostbite is a tissue injury that occurs when the body is exposed to extreme cold. Its path-ological mechanism is complex and has not been ful-ly elucidated. In high cold and high altitude areas, outdoor sports people have a high risk of injury, and severe frostbite has high disability and mortality. Ex-ploring the pathological mechanism of frostbite is helpful to determine the treatment methods and timing. At present, the clinical treatment of frostbite is mainly symptomatic treatment, such as drug treatment and surgical treatment, but the curative effect can not meet the clinical needs. Therefore, it is of great significance to seek more efficient drugs or treatment methods. This article reviews the rele-vant research progress in pathophysiological mecha-nism, clinical treatment, cellular and molecular path-ways of frostbite in recent years, in order to provide new ideas for future research and clinical treatment. 

Key words: frostbite, pathological mechanism, treatment, research progress

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