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中国临床药理学与治疗学 ›› 2024, Vol. 29 ›› Issue (10): 1174-1184.doi: 10.12092/j.issn.1009-2501.2024.10.011

• 综述与讲座 • 上一篇    下一篇

天然倍半萜内酯类成分抗胶质瘤作用机制的研究进展

严小婷1,王鑫烨2,白明2,姚国栋2   

  1. 1沈阳药科大学药学院,沈阳  110016,辽宁;2沈阳药科大学中药学院,沈阳  110016,辽宁
  • 收稿日期:2024-01-24 修回日期:2024-05-08 出版日期:2024-10-26 发布日期:2024-09-29
  • 通讯作者: 姚国栋,男,博士研究生,教授,博士生导师,研究方向:天然药物抗肿瘤作用与机制研究。 E-mail: guodong_yao@ 126.com
  • 作者简介:严小婷,女,研究方向:天然药物抗肿瘤作用与机制研究。 E-mail: fjll124482@163.com
  • 基金资助:
    国家自然科学基金(82104037);大学生创新创业训练计划项目(X202310163123)

Research progress on anti-glioma mechanism of natural sesquiterpene lactones

YAN Xiaoting1, WANG Xinye2, BAI Ming2, YAO Guodong2   

  1. 1 College of Medicine, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, China; 2 College of Chinese Medicine, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, China
  • Received:2024-01-24 Revised:2024-05-08 Online:2024-10-26 Published:2024-09-29

摘要:

胶质瘤是一种常见的原发性颅内肿瘤,恶性胶质瘤死亡率高、预后极差,尽管采取多种治疗干预措施,总体生存率依旧很低。倍半萜内酯是一类含有α-亚甲基-γ-内酯的天然产物,具有较强的抗肿瘤活性,近几年来已有多项关于倍半萜内酯类化合物抗胶质瘤作用的报道,如ACT001,是一种倍半萜内酯(小白菊内酯)的结构修饰物,已作为一种潜在抗癌药物进入临床试验阶段。本文就近几年已有研究的具有抗胶质瘤作用的倍半萜内酯的活性及作用机制进行综述。

关键词: 胶质瘤, 倍半萜内酯, 作用机制

Abstract:

Glioma is a common primary intracranial tumor. Malignant glioma has a high mortality rate and an inferior prognosis. Despite various therapeutic interventions, the overall survival rate is still meager. Sesquiterpene lactone is a kind of natural product containing α-methylene-γ-lactone, which has strong anti-tumor activity. In recent years, there have been many reports on the anti-glioma effect of sesquiterpene lactone compounds, such as ACT001, which is a structural modification of sesquiterpene lactone (Parthenolide) and has entered the clinical trial stage as a potential anticancer drug. This paper reviews the activity and mechanism of sesquiterpene lactones with anti-glioma effects, which have been studied in recent years.

Key words: glioma, sesquiterpene lactone, mechanism of action

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