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中国临床药理学与治疗学 ›› 2025, Vol. 30 ›› Issue (9): 1243-1252.doi: 10.12092/j.issn.1009-2501.2025.09.011

• 综述与讲座 • 上一篇    下一篇

Apelin：慢性肾脏疾病防治的新靶点

吕程果1，吴采倩1，米芊睿1，张国婧1，李玲1，叶啟发1,2   

  1. 1武汉大学中南医院，武汉大学肝胆疾病研究院，武汉大学移植医学中心，国家人体捐献器官获取质量控制中心，移植医学技术湖北省重点实验室，武汉  430071，湖北；2中南大学湘雅三医院，国家卫生健康委移植医学转化研究重点实验室，长沙  410013，湖南

  • 收稿日期:2024-11-18 修回日期:2025-02-06 出版日期:2025-09-26 发布日期:2025-09-09
  • 通讯作者: 李玲，女，博士，副主任药师，硕士生导师，主要研究方向：核受体与移植器官质量维护研究。 E-mail： zn000426@whu.edu.cn
  • 作者简介:吕程果，女，临床医学5+3学生，主要研究方向：核受体与移植器官质量维护研究。 E-mail： 2022305233100@whu.edu.cn
  • 基金资助:
    国家自然科学基金青年基金（82404775）；中央高校基本科研业务费专项资金青年教师资助项目（2042023kf0064）；武汉大学中南医院2024年科技创新培育基金（CXPY2024025）；武汉大学2024年大学生创新创业训练计划项目（S202410486384）

Apelin: A new target for the prevention and treatment of chronic kidney disease#br#

LYU Chengguo1, WU Caiqian1, MI Qianrui1, ZHANG Guojing1, LI Ling1, YE Qifa1,2   

  1. 1 Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, National Quality Control Center for Donated Organ Procurement, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan 430071, Hubei, China; 2 The 3rd Xiangya Hospital of Central South University, NHC Key Laboratory of Translational Research on Transplantation Medicine, Changsha 410013, Hunan, China
  • Received:2024-11-18 Revised:2025-02-06 Online:2025-09-26 Published:2025-09-09

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摘要：

慢性肾脏疾病（CKD）是由多种原因引起的慢性肾脏结构和功能障碍（肾脏损伤病史>3个月），其病因复杂，发病率高，最终将导致终末期肾病（ESRD）。常见慢性肾脏疾病包括糖尿病肾病、多囊肾病、肾源性尿崩症以及肾纤维化等。目前，对于慢性肾脏疾病仍缺乏有效的特异性治疗。Apelin系统是一种内源性生理调节剂。研究表明Apelin主要通过调控肾脏体液及血管、调节肾脏糖脂代谢及免疫等，参与上述疾病的发生发展。本文拟通过综述近几年Apelin在慢性肾脏疾病中的作用研究，为以Apelin为新靶点的肾脏疾病治疗与药物开发提供思路。

关键词: 慢性肾脏疾病, Apelin, 糖尿病肾病, 免疫相关肾病

Abstract:

Chronic kidney disease (CKD) is a chronic renal structural and functional disorder caused by multiple causes (history of kidney injury>3 months), with complex etiology and high incidence, which will eventually lead to end-stage renal disease (ESRD). Common chronic kidney diseases include diabetic nephropathy, polycystic nephropathy, nephrogenic diabetes insipidus and renal fibrosis. At present, there is still a lack of effective specific treatment for chronic kidney disease. The Apelin system is an endogenous physiological regulator. Studies have shown that Apelin is involved in the occurrence and development of the above diseases mainly through the regulation of kidney body fluids and blood vessels, and the regulation of kidney glucose and lipid metabolism and immunity. This article aims to review the role of Apelin in chronic kidney diseases in recent years, and provide ideas for the treatment and drug development of kidney diseases with Apelin as a new target.

Key words: chronic kidney disease, Apelin, diabetic nephropathy, Immune-associated nephropathy

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