性别因素对磷丙泊酚二钠抑制胃镜置入反应效力的影响

doi:10.12092/j.issn.1009-2501.2026.07.006

中国临床药理学与治疗学 ›› 2026, Vol. 31 ›› Issue (7): 908-912.doi: 10.12092/j.issn.1009-2501.2026.07.006

性别因素对磷丙泊酚二钠抑制胃镜置入反应效力的影响

张怡(), 方洁, 赵姝, 袁景丽, 任学军()

河南中医药大学第一附属医院麻醉科，郑州 450000，河南

收稿日期:2025-09-10 修回日期:2026-01-27 出版日期:2026-07-26 发布日期:2026-08-04
通讯作者: 任学军 E-mail:290364006@qq.com;jianpo@163.com
作者简介:张怡，男，硕士，主治医师，研究方向：围术期器官保护。E-mail：290364006@qq.com
基金资助:
河南省卫生健康委河南省中医药科研专项课题（2025ZY2010）

Effect of gender on the efficacy of fospropofol disodium in inhibiting the reaction of gastroscopy insertion

Yi ZHANG(), Jie FANG, Shu ZHAO, Jingli YUAN, Xuejun REN()

Department of Anesthesiology, the First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, Henan, China

Received:2025-09-10 Revised:2026-01-27 Online:2026-07-26 Published:2026-08-04
Contact: Xuejun REN E-mail:290364006@qq.com;jianpo@163.com

摘要/Abstract

摘要：

目的: 评价性别因素对磷丙泊酚二钠抑制胃镜置入反应效力的影响。方法: 本研究为前瞻性试验。选择拟行无痛胃镜检查患者，年龄18～64岁，BMI 18～25 kg/m²，ASA分级Ⅰ或Ⅱ级。所有患者随机分为3组：男性组（M组）、女性组（F组）、性别不限组（C组）。静脉注射纳布啡0.2 mg/kg，1 min后注射磷丙泊酚二钠，待改良警觉镇静评分（the modified observer's assessment of alertness and sedation，MOAA/S）≤3分后由同一名高年资主治医师行胃镜检查。按照改良Dixon 序贯法进行试验，每组首例患者磷丙泊酚二钠剂量均设定为10 mg/kg。若在进镜时患者出现影响检查操作的反应，判定为阳性反应，则下一例患者剂量增加1 mg/kg，否则降低1 mg/kg，出现7个阳性反应和阴性反应交叉点时终止该组试验。同时观察不良反应的发生。使用Probit回归分析法分别计算出每组患者磷丙泊酚二钠的半数有效剂量（ED₅₀）、95%有效剂量（ED₉₅）及95%可信区间（CI）。结果: M组磷丙泊酚二钠ED₅₀: 14.713 mg/kg（95% CI 14.044～14.988 mg/kg），ED₉₅: 16.854 mg/kg（95% CI 14.229～17.339 mg/kg），F组磷丙泊酚二钠ED_50: 12.938 mg/kg（95% CI 12.072～13.363 mg/kg），ED₉₅: 15.289 mg/kg（95% CI 12.265～16.293 mg/kg）。与M组比较，F组ED₅₀降低（P<0.05）。C组磷丙泊酚二钠ED₅₀: 13.915 mg/kg（95%CI 13.110～13.977 mg/kg），ED₉₅: 15.545 mg/kg（95%CI 13.311～15.675 mg/kg）。有15例（16%）患者出现感觉异常，2例（2%）患者出现呼吸抑制。结论: 性别因素影响磷丙泊酚二钠抑制胃镜置入反应的效力，女性的效力高于男性。

关键词: 性别因素, 胃镜检查, 磷丙泊酚二钠, 纳布啡, 剂量效应关系

Abstract:

AIM: To evaluate the effect of gender on the efficacy of fospropofol disodium in inhibiting the reaction of gastroscopy insertion. METHODS: This study was a prospective trial. Patients scheduled for painless gastroscopy, aged 18 to 64 years, with a BMI of 18 to 25 kg/m², and ASA physical status classification Ⅰ or Ⅱ, were selected and divided into three groups randomly: male group (M group), female group (F group), and gender-unrestricted group (C group). A dose of 0.2 mg/kg of nalbuphine was intravenously injected, followed by fospropofol disodium 1 minutes later. When the modified observer's assessment of alertness and sedation (MOAA/S) ≤3, gastroscopy was performed by an experienced senior physician. According to the improved Dixon sequential method, the dose of fospropofol disodium for the first patient was set at 10 mg/kg. If the patient showed any reaction affected the procedure during the insertion of the endoscope, it was judged as a positive reaction, and the dose for the next patient was increased by 1 mg/kg; otherwise, it was decreased by 1 mg/kg. The trial was terminated when there were 7 positive and negative reaction crossover points, and adverse reactions were observed. The dose-response relationship was calculated by probit regression analysis method. RESULTS: The ED₅₀ of fospropofol disodium in group M was 14.713 mg/kg (95% CI 14.044-14.988 mg/kg), ED₉₅ was 16.854 mg/kg (95% CI 14.229-17.339 mg/kg). In group F, ED₅₀ was 12.938 mg/kg (95% CI 12.072-13.363 mg /kg), and ED₉₅ was 15.289 mg/kg (95% CI 12.265-16.293 mg /kg). Compared with group M, the ED₅₀ of group F was decreased (P<0.05). The ED₅₀ of fospropofol disodium in group C was 13.915 mg/kg (95%CI 13.110-13.977 mg/kg), and ED₉₅ was 15.545 mg/kg (95%CI 13.311-15.675 mg/kg). Abnormal sensations occurred in 15 patients (16%), and respiratory depression occurred in 2 cases (2%). CONCLUSION: Gender factors influence the efficacy of sodium phosphopropofol in suppressing the response to endoscope insertion, with higher efficacy observed in females than that in males.

Key words: gender factors, gastroscopy, fospropofol disodium, nalbuphine, dose-response relationship

中图分类号:

R614

张怡, 方洁, 赵姝, 袁景丽, 任学军. 性别因素对磷丙泊酚二钠抑制胃镜置入反应效力的影响[J]. 中国临床药理学与治疗学, 2026, 31(7): 908-912.

Yi ZHANG, Jie FANG, Shu ZHAO, Jingli YUAN, Xuejun REN. Effect of gender on the efficacy of fospropofol disodium in inhibiting the reaction of gastroscopy insertion[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2026, 31(7): 908-912.

图/表 7

表 1

Table 1 Comparison of general data of three groups patients

Group	Age (years, $ \overline{x} $±s)	BMI (kg/m², $ \overline{x} $±s)	Examination time (min, $\overline{x} $±s)	Unconsciousness time (min, $\overline{x} $±s)	Recovery time (min, $\overline{x} $±s)	ASA (Ⅰ/Ⅱ)
Group M (n=32)	43.87±12.08	22.82±2.03	7.49±1.48	3.50±0.47	25.26±3.99	12/21
Group F (n=30)	43.41±11.54	22.89±2.05	7.51±1.46	3.54±0.48	25.20±4.00	16/14
Group C (n=29)	44.13±11.78	22.91±2.02	7.50±1.43	3.53±0.47	25.22±3.92	11/18

图 1

Fig.1 Sequential diagram of fospropofol disodium for painless gastroscopy in male patients when combined with nalbuphine

图 2

Fig.2 Dose-effect relationship of fospropofol disodium in male patients

图 3

Fig.3 Sequential diagram of fospropofol disodium for painless gastroscopy in female patients when combined with nalbuphine

图 4

Fig.4 Dose-effect relationship of fospropofol disodium in female patients

图 5

Fig.5 Sequential diagram of fospropofol disodium for painless gastroscopy when combined with nalbuphine

图 6

Fig.6 Dose-effect relationship of fospropofol disodium

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性别因素对磷丙泊酚二钠抑制胃镜置入反应效力的影响

Effect of gender on the efficacy of fospropofol disodium in inhibiting the reaction of gastroscopy insertion

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