盐酸羟考酮控释片复合窄谱中波紫外线治疗带状疱疹神经痛的疗效

doi:10.12092/j.issn.1009-2501.2018.03.016

摘要/Abstract

摘要：

目的:探讨盐酸羟考酮控释片复合窄谱中波紫外线治疗带状疱疹神经痛的疗效。方法:采用前瞻性研究方法，选择2013年9月到2016年2月在本院诊治的带状疱疹神经痛患者120例，根据信封随机抽签原则分为观察组与对照组各60例，两组都给予抗病毒基础治疗，对照组采用窄谱中波紫外线治疗仪照射治疗，观察组在对照组治疗的基础上口服盐酸羟考酮控释片，均治疗观察14 d。结果: 观察组的皮损消退时间为(6.18±1.05) d，明显少于对照组（7.93±1.36）d(P<0.05)。观察组治疗后的疼痛与皮损评分分别为(2.33±1.38)分和(1.26±0.76)分，均明显低于对照组的(4.46±1.93)分和(3.56±1.18)分(P<0.05)，且均明显低于治疗前(P<0.05)。在治疗期间两组均未出现严重不良反应，观察组的便秘、恶心呕吐、头晕等不良反应发生情况与对照组对比无统计学差异(P>0.05)。结论:盐酸羟考酮控释片复合窄谱中波紫外线治疗带状疱疹神经痛能有效缓解疼痛与皮损症状，安全性佳，从而促进患者的康复。

关键词: 盐酸羟考酮控释片, 窄谱中波紫外线, 带状疱疹神经痛, 皮损, 不良反应

Abstract:

AIM: To evaluate the curative effects of oxycodone hydrochloride controlled-release tablets plus NB-UVB in the treatment of herpes zoster neuralgia. METHODS: A prospective study method was adopted; one hundred and twenty cases of patients with herpes zoster treated by our hospital from September 2013 to February 2016 were selected and were equally divided into the observation group and control group according to the random-envelope principles. Both groups received antiviral treatment, and the control group was given NB-UVB therapy, while the observation group received oxycodone hydrochloride controlled release tablets combined with NB-UVB therapy; the treatment cycle was 14 days. RESULTS: The skin lesion regression time of the observation group was (6.18±1.05) d, which was significantly shorter than (7.93±1.36) d in the control group (P<0.05). The pain and skin lesions scores in the observation group after treatment were (2.33±1.38) points and (1.26±0.76) points, which were significantly lower than (4.46±1.93) points and (3.56±1.18) points of the control group (P<0.05), and that before treatment (P<0.05). There were no severe adverse reactions in the two groups during the treatment, and the nausea and vomiting, constipation, drowsiness, dizziness and other adverse reactions compared between the two groups showed no significant difference (P>0.05). CONCLUSION: Oxycodone hydrochloride controlled release tablets combined with NB-UVB in the treatment of herpes zoster neuralgia can effectively and safely relieve the pain and skin lesions so as to promote the patient's rehabilitation.

Key words: oxycodone hydrochloride controlled-release tablets, NB-UVB, herpes zoster, skin lesions, adverse reaction

中图分类号:

R752.1

徐丽丽，王云甫，全变瑞. 盐酸羟考酮控释片复合窄谱中波紫外线治疗带状疱疹神经痛的疗效[J]. 中国临床药理学与治疗学, 2018, 23(3): 333-336.

XU Lili, WANG Yunfu, QUAN Bianrui. Effects of oxycodone hydrochloride controlled release tablets plus NB-UVB in the treatment of herpes zoster neuralgia[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2018, 23(3): 333-336.

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