宫腔内注射hCG在子宫内膜异位症患者冻融胚胎移植周期中的应用与效果

doi:10.12092/j.issn.1009-2501.2018.11.015

中国临床药理学与治疗学 ›› 2018, Vol. 23 ›› Issue (11): 1287-1291.doi: 10.12092/j.issn.1009-2501.2018.11.015

宫腔内注射hCG在子宫内膜异位症患者冻融胚胎移植周期中的应用与效果

徐芝慧，周洁春，陈惠南，王安兰

温州医科大学附属第一医院生殖医学中心，温州 325000，浙江

收稿日期:2018-07-05 修回日期:2018-08-01 出版日期:2018-11-26 发布日期:2018-11-22
作者简介:徐芝慧，女，硕士，主治医师，研究方向：生殖内分泌。 Tel：0577-88069643 E-mail：xzhwmc@163.com
基金资助:
温州市科技局公益性科技计划项目（Y20170593）

Application and effect of intrauterine injection of human chorionic gonadotropin in frozen-thawed embryo transfer cycle for endometriosis patients

XU Zhihui, ZHOU Jiechun, CHEN Huinan, WANG Anlan

Department of Reproductive Center，First Affiliated Hospital of Wenzhou Medical University，Wenzhou 325000，Zhejiang，China

Received:2018-07-05 Revised:2018-08-01 Online:2018-11-26 Published:2018-11-22

摘要/Abstract

摘要：

目的: 探讨冻融胚胎移植前行宫腔内注射人绒毛促性腺激素（hCG）对子宫内膜异位症患者冻融胚胎移植周期妊娠结局的影响。方法: 回顾性分析子宫内膜异位症患者冻融胚胎移植周期228个，按照宫腔内是否注射hCG分为宫腔内注组（50个周期）和无宫腔内注射的对照组（178个周期）。比较两组年龄、不孕年限、体质量指数、激素水平、内膜厚度、胚胎质量，以及临床妊娠率、活产率，分析子宫内膜异位症冻融胚胎移植周期活产的相关影响因素。结果: 两组患者年龄等基本特征以及激素、内膜厚度、胚胎质量等方面均无统计学差异（P＞0.05），但宫腔内注组活产率高于对照组（P＜0.05），且流产率低于对照组（P＜0.05）。年龄和宫腔内注射hCG是活产的独立影响因素。结论: 子宫内膜异位症患者冻融胚胎移植前行宫腔内注射hCG有利于提高此类患者冻融胚胎移植后的活产率，降低流产率。

关键词: 子宫内膜异位症, 冻融胚胎移植, 宫腔注射, 绒毛膜促性腺激素

Abstract:

AIM: To investigate the effect of intrauterine injection of human chorionic gonadotropin (hCG) upon pregnancy outcomes following frozen-thawed embryo transfer (FET) for endometriosis (EMs) patients. METHODS: We retrospectively collected 228 FET cycles of EMs patients, and divided them into intrauterine injection group (50 cycles) and control group (178 cycles). Age, infertile duration, body mass index, hormone profile, endometrial thickness, embryo quality, clinical pregnancy rate and live birth rate were compared, the related factors affecting live birth were further analyzed. RESULTS: No significant difference was detected when baseline character, hormone change, endometrial thickness and embryo quality were compared between two groups, while live birth rate was found statistically higher and miscarriage rate was remarkably lower in intrauterine injection group. Age and intrauterine injection of hCG were two independent factors affecting live birth in EMs following FET. CONCLUSION: Intrauterine injection of hCG prior to FET can improve the live birth rate and reduce the miscarriage rate for EMs patients.

Key words: endometriosis, frozen-thawed embryo transfer, intrauterine injection, human chorionic gonadotropin

中图分类号:

徐芝慧，周洁春，陈惠南，王安兰. 宫腔内注射hCG在子宫内膜异位症患者冻融胚胎移植周期中的应用与效果[J]. 中国临床药理学与治疗学, 2018, 23(11): 1287-1291.

XU Zhihui, ZHOU Jiechun, CHEN Huinan, WANG Anlan. Application and effect of intrauterine injection of human chorionic gonadotropin in frozen-thawed embryo transfer cycle for endometriosis patients[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2018, 23(11): 1287-1291.

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宫腔内注射hCG在子宫内膜异位症患者冻融胚胎移植周期中的应用与效果

Application and effect of intrauterine injection of human chorionic gonadotropin in frozen-thawed embryo transfer cycle for endometriosis patients

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