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中国临床药理学与治疗学 ›› 2010, Vol. 15 ›› Issue (9): 1008-1011.

• 基础研究 • 上一篇    下一篇

人工麝香对大鼠高脂血症影响的实验研究

李海涛1,2, 朱雪晶1, 吴其标2   

  1. 1南京中医药大学药学院教学实验中心,南京 210046,江苏;
    2澳门科技大学中医药学院,澳门 00853
  • 收稿日期:2010-06-11 修回日期:2010-09-18 出版日期:2010-09-26 发布日期:2020-09-17
  • 作者简介:李海涛,男,教授,研究方向:心血管药理。Tel: 15952016326, E-mail: lihaitao0003@sina.com
  • 基金资助:
    澳门科学技术发展基金项目资助(027/2007/A2)

Effects of artificial musk on hyperlipemia in rats

LI Hai-tao1,2, ZHU Xue-jing1, WU Qi-biao2   

  1. 1Department of Pharmacology, Nanjing University of Traditional Chinese Medicine, Nanjing 210046, Jiangsu, China;
    2Macao Technology University, Macao 00853, China
  • Received:2010-06-11 Revised:2010-09-18 Online:2010-09-26 Published:2020-09-17

摘要: 目的: 观察人工麝香对大鼠高脂血症的影响。方法: SD大鼠,随机分为6组,每组10只。空白组正常饲养,其余5组高脂乳剂灌胃同时给药,连续4周。末次给药后1 h,取血离心制备血清,检测TC、TG、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)含量,用双抗体夹心ELISA法测定血清C反应蛋白(CRP)、内皮素-1(ET-1)、肿瘤坏死因子α(TNF-α)的变化。结果: 与模型组比较,人工麝香低、中、高剂量(3、6、12 mg/kg)能明显降低TC、TG的升高(P<0.05),对LDL-C的升高有一定的降低作用;人工麝香高剂量能明显降低大鼠血清CRP、ET-1、TNF-α(P<0.05)。结论: 人工麝香对大鼠高脂血症具有明显的调节作用。

关键词: 人工麝香, 高脂血症, 血脂

Abstract: AIM: To investigate the effect of artificial musk on hyperlipermia in rats.METHODS: SD rats were randomly divided into six groups: control group, model group, simvastatin group, artificial musk low,middle and high groups. The fatty emulsion were given to model group and treated groups, but none to control group. The levels of total cholesterol(TC), triglyceride(TG), low density lipoprotein cholesterol(LDL-C) and high density lipoprotein cholesterol(HDL-C) were measured . The levels of serum CRP,ET-1 and TNF-α were determined by double-antibody sandwich ELISA.RESULTS: The function in reducing the content of serum TC,TG were different between artificial groups and model group(P<0.05). Artificial musk high dose group decreased the serum levels of CRP,ET-1 and TNF-α(P<0.05).CONCLUSION: Artificial musk can improve hyperlipermia in rats.

Key words: Artificial musk, Hyperlipermia, Lipid

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