癌症预防中的Keap1-Nrf2-ARE通路

摘要/Abstract

摘要： 癌症的治疗至今仍未取得重大进展,因此做好癌症的预防工作就尤为关键。目前有很多自然物质(如从植物中提取的抗氧化剂)或化学合成物质(如添加在食品中的抗氧化剂)被用来预防癌症。最近发现,有些癌症预防物是通过诱导二相抗氧化酶来清除体内的致癌物质或其它毒物,而且这种诱导作用是通过Keap1-Nrf2-ARE信号通路。因此,对这一通路的了解有利于拓展癌症的研究及预防。

关键词: 癌症, 预防, Keap1-Nrf2-ARE信号通路

Abstract: Chemoprevention of cancers is still very important since we have not got effective treatments for them.Many natural products (e.g.extracts from plants) or chemical synthetic substances (e.g.additives in foods) were used as chemoprevention regents.Some of them fight the carcinogens or other toxins through induction of the phase 2 antioxidant enzymes.Recently, it is wildly believed that the mechanism of this induction is the activation of Keap1-Nrf2-ARE signaling pathway.Thus understanding of this signaling pathway will widen the field of the cancer research and chemoprevention.

Key words: cancer, chemoprevention, Keap1-Nrf2-ARE signaling pathway

中图分类号:

R73-36⁺2

刘晓平. 癌症预防中的Keap1-Nrf2-ARE通路[J]. 中国临床药理学与治疗学, 2008, 13(6): 716-720.

LIU Xiao-ping. Keap1-Nrf2-ARE signaling pathway in the chemoprevention of cancer[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2008, 13(6): 716-720.

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