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中国临床药理学与治疗学 ›› 2008, Vol. 13 ›› Issue (10): 1139-1143.

• 基础研究 • 上一篇    下一篇

复方中药对多囊卵巢综合征模型大鼠血清性激素、瘦素水平的影响

邓阿黎1, 周忠明1, 向楠1, 姜惠中1, 张亚兵2, 金晶1, 余念1, 陈露1   

  1. 1湖北中医学院附属医院妇产科, 武汉 430061, 湖北;
    2武汉大学中南医院中医科, 武汉 430070, 湖北
  • 收稿日期:2008-08-07 修回日期:2008-10-05 出版日期:2008-10-26 发布日期:2020-10-19
  • 作者简介:邓阿黎, 医学博士, 主治医师, 主要从事中西医结合妇产科疾病的临床、科研及教学工作。Tel:13971220416 E-mail:dengali027@yahooo.com.cn
  • 基金资助:
    武汉市科技厅科技攻关项目(20055102032-4)

Influence of traditional Chinese medicine on PCOS rat model serum sex hormone T, FSH, LH, and Leptin

DENG A-li1,ZHOU Zhong-ming1, XIANG Nan1, JIANG Hui-zhong1, ZHANG Ya-bing2, JING Jing1, YU Nian1, CHEN Lu1   

  1. 1Department of Gynaecology and Obstetrics Affiliated Hospital, Hubei College of Traditional Chinese Medicine, Wu-han430061, Hubei, China;
    2Department of Traditional Chinese Medicine Zhongnan Hospital of Wuhan University,Wuhan430070, Hubei, China
  • Received:2008-08-07 Revised:2008-10-05 Online:2008-10-26 Published:2020-10-19

摘要: 目的: 观察多囊卵巢综合征(PCOS) 模型大鼠血清性激素 T 、FSH 、LH 及瘦素(Leptin) 水平的变化, 探讨复方中药对 PCOS 模型大鼠生殖内分泌系统的影响。方法: 本实验采用 Poresky 法进行造模, 并分别以中药、西药(罗格列酮)、中西药联合用药治疗, 观察治疗后大鼠体重 、血清性激素及Leptin 水平的变化, 并进行 Leptin 水平与 FSH、LH 、LH/FSH 、T 、WEIGHT 的相关分析 。结果: 复方中药能降低血清 T 、LH 、Leptin 水平及 LH/FSH 比值, 且血清 Leptin 水平与 LH 、T 呈正相关。结论:复方中药能改善 PCOS 模型大鼠的生殖内分泌功能, 降低血清 Leptin 水平。

关键词: 中药, 多囊卵巢综合征, T, FSH, LH, 瘦素

Abstract: AIM: To observe the changes of serum sex hormone T, FSH, LH and Leptin, and explore the influence of traditonal Chinese medicine complex on the reproduction endocrine system in PCOS rat model. METHODS: PCOS rat model was established by Poresky method, the changes of the rats weight, serum sex hormone T,FSH, LH and Leptin were observed af-ter the treatment with traditional Chinese medicine, western medicine (rosiglitazone) , united medication, respectively, and the correlations of serum Leptin levels with FSH, LH, LH/FSH, T, Weight were analyzed. RESULTS: The traditional Chinese medicine group could decrease serum sex hormone T, LH, Leptin level and the LH/FSH, Leptin level and LH, T were positive correlated in model rats. CONCLUSION: The traditional Chinese medicine can improve reproduction en-docrine system functoins and decrease serum Leptin levels on PCOS rat model.

Key words: traditional Chinese medicine, PCOS, T, FSH, LH, Leptins

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