关键词: 复方丹参注射液, 肝素, 脂多糖, 纤维蛋白 ( 原) , 血小板

Abstract: AIM :To evaluate the effects of com- pound salivia miltorrhiza injection on an experimental model of kidney thrombus induced by lipopolysaccharide ( LPS) .METHODS:The model of microvascular throm- bosis in the rabbits' kidney was performed by the method of Hermida, which was induced by infusing LPS .Treat- ments were begun simultaneously with LPS infusion, through the contralateral marginal ear vein .Six different groups were established :NS 10 ml·h^-1 was infused as the negative control group, compound salivia miltorrhiza injection was infused with the dosage of 0 .1 ( Low-dose) , 0 .2 ( medium-dose ) , and 0 .4 ( high-dose ) ml·kg ^-1·h^-1 , heparin 600, 000 IU·kg ^-1·h^-1 as positive control group .The further rabbits, which were given nei- ther LPS nor compound salivia miltorrhiza injection, were infused with saline solution through both marginal ear veins .The measurement of fibrinogen concentrations and platelet counts were used to assess the degradation of mi- crovascular thrombosis .Kinney sections were examined for the presence of fibrin microthrombi .^RESULTS: Compound salivia miltorrhiza injection was infused with the dosage of 0 .1 ( Low-dose) , 0 .2 ( medium-dose) , and 0 .4 ( high-dose) ml·kg ^-1·h^-1 , and the fibrinogen con- centrations and blood platelet counts were improved, and the fibrin deposition was degraded .CONCLUSION: Compound salivia miltorrhiza injection can inhibit effec- tively LPS-induced renal microvascular thrombosis .

Key words: compound salivia miltorrhiza injection , heparin ;LPS ;fibrino( gen) ;platelet