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中国临床药理学与治疗学 ›› 2007, Vol. 12 ›› Issue (7): 786-789.

• 基础研究 • 上一篇    下一篇

阿托伐他汀对兔缺血再灌注损伤的保护作用

周逸, 陈曼华, 刘锦华, 张利芸   

  1. 武汉市中心医院心血管内科, 武汉 430014, 湖北
  • 收稿日期:2007-02-26 修回日期:2007-06-13 出版日期:2007-07-26 发布日期:2020-10-27
  • 通讯作者: 陈曼华, 女, 主任医师, 教授, 研究方向:冠心病的介入治疗及基础研究。Tel:027-82811080-8210 E-mail:sjcmh@yahoo.com.cn
  • 作者简介:周逸,男,硕士,主治医师,研究方向:心血管药理。Tel:027-82811080-8209 E-mail:zy1295090909@yahoo.com.cn

Protection of atorvastatin on cardiac function following ischemia-reperfusion injury in rabbits

ZHOU Yi, CHEN Man-hua, LIU Jin-hua, ZHANG Li-yun   

  1. Department of Cardiology, Wuhan Central Hospital, Wuhan 430014, Hubei, China
  • Received:2007-02-26 Revised:2007-06-13 Online:2007-07-26 Published:2020-10-27

摘要: 目的: 观察阿托伐他汀(ATV) 对心肌缺血再灌注损伤的影响以及诱导型一氧化氮合酶(iNOS) 在其中的作用。方法: 将健康雄性新西兰大耳白兔随机分成模型对照组、ATV 组、ATV+S-甲基异琉脲硫酸盐(SMT) 组、SMT 组, 每组8 只。进行40 min 局部缺血和240 min 再灌注, 观察各组血流动力学、血液生物化学及一氧化氮合酶的变化。结果: 缺血再灌注使左室发展压(LVDP) 和压力上升最大速率(+dp/dtmax) 分别下降24.6%和35.3%;3 d ATV 预处理(10 mg·kg-1·d-1) 使缺血再灌注后LVDP 和+dp/dtmax的下降幅度分别减小21.7%和41.3%, 使心肌型肌酸激酶同功酶(CK-MB) 和乳酸脱氢酶(LDH-1)分别降低31.4%和19.1%, 使iNOS 上升102.6%;ATV+SMT 组LVDP 和+dp/dtmax 的下降幅度、CKMB、LDH-1、iNOS 均和模型对照组无明显差异。结论: ATV 预处理通过上调iNOS 减轻心肌缺血再灌注损伤。

关键词: 阿托伐他汀, 兔, 心肌, 缺血再灌注, 一氧化氮合酶

Abstract: AIM: To observe the effect of atorvastatin (ATV) on myocardial ischemia-reperfusion injury and the role of inducible nitric oxide synthase (iNOS). METHODS: The rabbits were randomly divided into control group, ATV group, ATV+S-Methylisothiourea sulfate (SMT) group, SMT group.All rabbits were subjected to 40 min ischemia and 240 min reperfusion.The hemodynamic variables, CK-MB, LDH-1 and nitric oxide synthase were detected after reperfusion. RESULTS: LVDP and+dp/dtmax decreased by 24.6% and 35.3%respectively following ischemia-reperfusion.Pre-treated by ATV (10 mg·kg-1·d-1) for three days, LVDP and+dp/dtmax decreased by 21.7% and 41.3%, CK-MB and LDH-1 by 31.4% and 19.1% and iNOS increased to 102.6%.The reduction of LVDP and+dp/dtmax, CKMB, LDH-1 and iNOS in ATV+SMT group was no statistically significant with those in control group. CONCLUSION: ATV pretreatment protected myocardial ischemia-reperfusion injury by upregulating iNOS.

Key words: atorvastatin, rabbit, myocardium, ischemia-reperfusion, nitric oxide synthase

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