肿瘤疼痛研究进展

中国临床药理学与治疗学 ›› 2006, Vol. 11 ›› Issue (12): 1332-1335.

肿瘤疼痛研究进展

蒋守洋, 袁胜涛¹

江苏省射阳县盘湾中心卫生院, 射阳 224312, 江苏;
¹中国药科大学新药筛选中心, 南京 210038, 江苏

收稿日期:2006-10-26 修回日期:2006-11-10 出版日期:2006-12-26 发布日期:2020-11-06
通讯作者: 袁胜涛, 男, 博士, 副研究员, 研究方向:抗肿瘤药物研发、分子靶点的建立和分子作用机理研究。
作者简介:蒋守洋, 男, 本科, 主治医师, 研究方向:临床内科。Tel:0515-2996755 　E-mail:jsy bw@yahoo.com.cn

Researeh progress for tumor ache

JIANG Shou-yang, YUAN Sheng-tao¹

Panuan Hospital of Sheyang Country in Jiangsu Provihce, Sheyang 224312, Jiangsu, China;
¹The Natinal Drug Lentre of China Pharmaceutical University, Nanjing 210038, Jiangsu, China

Received:2006-10-26 Revised:2006-11-10 Online:2006-12-26 Published:2020-11-06

摘要/Abstract

摘要： 疼痛是癌症患者最常见且最难控制的症状,也是影响患者生活质量的重要因素。肿瘤疼痛具有不同于其它慢性疼痛的独特机制。近几年已建立了多种小鼠、大鼠肿瘤疼痛模型, 模拟临床肿瘤侵入神经或骨转移产生的疼痛, 以及化疗诱导的外周神经病变性疼痛, 且成功用于治疗肿瘤疼痛药物的评价。随着分子生物学技术的发展和对疼痛机理的深入理解, 细胞和基因水平的镇痛治疗作为新的干预手段,已成为传统三阶段治疗方法的有效补充。

关键词: 肿瘤, 疼痛, 模型, 转移

Abstract: Pain is a major symptom in patients suffering from cancer and also the most important factor which affects the quality of patients' lives.Cancer pain has unique mechanism from that of other kinds of pain.Recent years, there have established sorts of cancer pain models in rats and mice and modeled clinical pains caused by tumor intruding nerves or osseous metastasis, or pain of chemotherapy-induced peripheral neuropathy, and they have been used in evaluations of cancer pain treatment drugs.With the development of molecular biology technology and comprehend of pain mechanisms, relieve pain treatments in cell and gene levels as a new method have become an effective addition to traditional 3-stePanalgesic ladder.

Key words: cancer, pain, model, metastasis

中图分类号:

R441.1

蒋守洋, 袁胜涛. 肿瘤疼痛研究进展[J]. 中国临床药理学与治疗学, 2006, 11(12): 1332-1335.

JIANG Shou-yang, YUAN Sheng-tao. Researeh progress for tumor ache[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2006, 11(12): 1332-1335.

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