1 Guyatt G,Sackett D,TaylorDW,Chong J,Roberts R,Pugsley S.Determining optimal therapy-randomized trials in individual patients[J].N Engl JMed,1986;314:889-92
2 Guyatt G,Sackett D,Adachi J,Roberts R,Chong J,Rosen-bloom D,et al.A clinician' s guide forconduction randomized trials in individual patients[J].CAMJ,1988;139:497-503
3 赖世隆.临床医学研究设计概要[A].见:赖世隆,主编.中西医结合临床科研方法学[M].第 1 版.北京:科学出版社,2003:63
4 McLeod RS,TaylorDW,Cohen Z,Cullen JB.Single-patient ran-domised clinical trial.Use in determining optimum treatment forpatient with inflammation of Kock continent ileostomy reservoir[J].Lancet,1986;1:726-8
5 Mahon J,Laupacis A,DonnerA,Wood T.Randomized study of n of 1 trials versus standard practice[J].BMJ,1996;312:1069-74
6 March L,Irwig L,Schwarz J,Simpson J,Chock C,Brooks P.N of 1 Trials Comparing a Non-Steroidal Anti -Inflammatory Drug with Paracetamol inOsteoarthritis[J].BMJ,1994;309:1041-45
7 ChatellierG,Day M,Bobrie G,Menard J.Feasibility Study of N-of -1 TrialsWith Blood Pressure Self-Monitoring in Hypertension[J].Hypertension,1995;25:294-301
8 Guyatt GH,KellerJL,Jaeschke R,Rosenbloom D,Adachi JD,Newhouse MT.The n-of -1 randomized controlled trial:clinical usefulness.Ourthree-yearexperience[J].Annals of Internal Medicine,1990;112:293-9
9 Johannessen T.Controlled trials in single subjects.I.Value in clinical medicine[J].BMJ,1991;303:173-4
10 Miquel P,Francisco B,Ildefonso H,Jesus V.N of 1 trials:Research isneededinto why such trials are not more widely used[J].BMJ,1996,313:427
11 Saunders KB.Could it be that editorially you have somewhat exaggerated the point[J] ?BMJ,1994;309:1584
12 Lewis JA.Controlled trials in single subjects.II.Limitationsof use[J].BMJ,1991;303:175-6
13 Guyatt GH,Heyting A,Jaeschke R,KellerJ,Adachi JD,Roberts RS.Controlled clinical trials[J].1990;11:88-100
14 Brad J,Edward M.N-of-1 randomized controlled trials in com-plementary and alternative medicine[R].http: www.camerar-esearchnetwork.ab.ca research 2004abs6.html |
