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中国临床药理学与治疗学 ›› 2005, Vol. 10 ›› Issue (3): 343-347.

• 研究原著 • 上一篇    下一篇

蝙蝠葛酚性碱抗氧化和降脂作用的实验研究

刘长丽, 曾繁典1   

  1. 伊春药业有限公司药物研究所, 伊春153000, 黑龙江;
    1华中科技大学同济医学院药理系, 武汉430030, 湖北
  • 收稿日期:2004-10-18 修回日期:2004-11-23 出版日期:2005-03-26 发布日期:2020-11-18
  • 通讯作者: 曾繁典, 男, 教授, 博士生导师, 中国药理学会副理事长, 研究方向:临床药理和心血管药理。Tel:027-83630652 E-mail:fdzeng@mails.tjmu.edu.cn
  • 作者简介:刘长丽, 女, 硕士研究生, 主要从事新药研究开发及心血管药理研究工作。Tel:0458-3986436 E-mail:lucyliu7651@yahoo.com.cn

Antioxidative and lipid-lowering effects of phenolic alkaloids of Menispermum dauricum

LIU Chang-li, ZENG Fan-dian1   

  1. Institute of Materia Medica, Yichun Pharmaceuticutical Lt.co, Yichun 153000, Heilongjiang, China;
    1Department of Pharmacology, Tongji Medical College, HuazhongUniversity of Science and Technology, Wuhan 430030, Hubei, China
  • Received:2004-10-18 Revised:2004-11-23 Online:2005-03-26 Published:2020-11-18

摘要: 目的:研究蝙蝠葛酚性碱(PAMD)抗氧化和降脂作用。方法:通过TBA 法测定大鼠肝匀浆自发和诱导的脂质过氧化产物MDA 的量, 研究PAMD 对脂质过氧化的作用;利用Fenton 反应和Marklund 反应研究PAMD 对羟自由基和超氧阴离子的清除作用;通过建立大鼠高脂血症模型, 研究PAMD 对高脂模型动物的降脂及抗氧化保护作用。结果:PAMD 能抑制自发的和诱导的脂质过氧化产物MDA 的生成,对化学体系产生的羟自由基和超氧阴离子有清除作用;能降低高脂模型动物血清及肝中TC、TG、LDL、MDA 含量, 对血清SOD 活性和HDL 含量有一定的升高作用。结论:PAMD 具有抑制体外脂质过氧化和清除自由基作用, 能调节高脂模型动物血脂水平。

关键词: 蝙蝠葛酚性碱, 高脂模型, 脂质过氧化, 抗氧化, 清除自由基, 降脂

Abstract: AIM: To investigate the antioxidative effects of phenolic alkaloids of Menispermum dauricum (PAMD)and its lowering lipid effects.METHODS: The effects of PAMD on spontaneous and induced liver homogenate lipid peroxidation were studied by TBA method for testing the content of MDA.Reactions of Fenton and Marklund were used to test the scavenging capacity of PAMD on superoxide anion and hydroxyl radicals.The lipid-lowering capacity of PAMD was observed on hyperlipidemic animal model.RESULTS: PAMD inhibited the production of MDA in spontaneous and induced peroxidation of liver homogenate.It also scavenged superoxide anions and hydroxyl radicals.CONCLUSION: PAMD can inhibit the lipid peroxidate in vitro, scavenge free radicals, lower the contents of TC, TG, LDL, and MDA in serum and liver and heighten the activity of SOD and the content of HDL in serum.

Key words: phenolicalk aloids of Menispermum dauricum, hyperlipidemic model, lipid peroxidate, antioxidant, oxygen free radicals, lipid

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