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中国临床药理学与治疗学 ›› 2004, Vol. 9 ›› Issue (8): 945-948.

• 研究原著 • 上一篇    下一篇

TGFβ1型受体在2型糖尿病大鼠肾皮质的表达及缬沙坦调节作用

郑民, 何敏, 徐济良, 殷晓芹   

  1. 南通医学院药理学教研室, 南通226001, 江苏
  • 收稿日期:2004-04-24 修回日期:2004-06-22 出版日期:2004-08-26 发布日期:2020-11-20
  • 作者简介:徐济良,男,教授,硕土生导师,研究方向:心血管药理学研究。Tel:0513-5051727 E-mail:jlxu@ntmc.edu.cn
  • 基金资助:
    江苏省教育厅科学研究基金资助项目(№JH 01-076)

Expression of type Ⅰ transforming growth factor β receptor in renal cortex of streptozotocin-induced type Ⅱ diabetic rats and the regulation of valsartan

ZHENG Min, HE Min, XU Ji-Liang, YIN Xiao-Qin   

  1. Department of Pharmacology, Nantong Medical College, Nantong 226001, Jiangsu, China
  • Received:2004-04-24 Revised:2004-06-22 Online:2004-08-26 Published:2020-11-20

摘要: 目的: 研究转化生长因子β1型受体(TβR-Ⅰ)在2型糖尿病大鼠肾皮质中的表达及血管紧张素Ⅱ受体拮抗剂缬沙坦对其调节作用。方法: 制备2型糖尿病大鼠模型,在缬沙坦治疗8 周后,取肾脏,采用逆转录聚合酶链式反应(RT-PCR)方法检测肾皮质TβR-ⅠmRNA 的表达。结果: 糖尿病组大鼠肾皮质TβR-Ⅰ mRNA 的表达(0.719 ±0.139)较正常组(0.257 ±0.116)明显增高(P<0.01);糖尿病+缬沙坦组(0.341 ±0.11),与糖尿病组比较,显著下降(P<0.01)。结论: 2型糖尿病大鼠肾皮质中TβR-Ⅰ 表达是上调的,缬沙坦对TβR-Ⅰ有抑制作用。

关键词: 2 型糖尿病肾病, 缬沙坦, 转化生长因子-β, 大鼠

Abstract: AIM: To study the expression of typeⅠtransforming growth factor β (TβR-Ⅰ) in renal cortex in streptozotocin-induced type Ⅱ diabetic mellitus and the regulation of valsartan.METHODS: The rat models of type Ⅱ diabetic rats were made.At the end of the 20th weeks, the kidneys were taken out to measure the expression of TβR-ⅠmRNA by RT-PCR.RESULTS: The expression of TβR-Ⅰ mRNA in diabetic rats without any therapy (0.72 ±0.14) was higher than that in control(0.26 ±0.12) (P<0.01), and the expression of TβR-ⅠmRNA in the diabetic rats treated with valsartan (0.34 ±0.11) was lower than that in the diabetic rats without any therapy (P<0.01).CONCLUSION: The expression of TβR-ⅠmRNA increases significantly in renal cortex of type Ⅱ diabetic rats.Valsartan can decrease the expression of TβR-ⅠmRNA in renal cortex of type Ⅱ diabetic rats.

Key words: type Ⅱ diabetic nephropathy, valsartan, transforming growth factor beta, rat

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