氯胺酮对腹腔感染脓毒症小鼠生存率的影响

中国临床药理学与治疗学 ›› 2004, Vol. 9 ›› Issue (8): 942-944.

氯胺酮对腹腔感染脓毒症小鼠生存率的影响

刘芬, 陈金和¹, 李声华, 赵文辉, 艾永循

江汉大学附属医院麻醉科, 武汉430015, 湖北

收稿日期:2004-04-15 修回日期:2004-06-26 出版日期:2004-08-26 发布日期:2020-11-20
通讯作者: 1陈金和,男,硕士研究生导师,研究方向:神经药理学,工作单位:武汉大学医学院药学系。Tel:027-82440793 E-mail:killerlsh2000@yahoo.com.cn
作者简介:刘芬,女,硕士,讲师,主治医师。

Effects of ketamine on cumulative survival in septic mice induced by cecal ligation and puncture

LIU Fen, CHEN Jin-He, LI Sheng-Hua, ZHAO Wen-Hui, AI Yong-Xun

Department of Anesthesiology, the Affiliated Hospital of JiangHan University, WuHan, 430015, Hubei, China

Received:2004-04-15 Revised:2004-06-26 Online:2004-08-26 Published:2020-11-20

摘要/Abstract

摘要： 目的: 探讨早期使用氯胺酮是否延迟盲肠结扎穿孔(CLP)所致脓毒症小鼠的死亡时间。方法: 60只CLP小鼠,分别于术后1、6 h 腹腔注射氯胺酮0、3、6、12 mg·100 g^-1,观察小鼠死亡情况并比较累计生存率。结果: 氯胺酮延长CLP小鼠死亡时间(P<0.05);氯胺酮6 mg·100 g^-1组小鼠生存时间明显长于3 mg·100 g^-1组和12 mg·100 g^-1组(P<0.05)。结论: 氯胺酮延迟CLP小鼠死亡时间,并呈现剂量依赖性。

关键词: 氯胺酮, 盲肠结扎穿孔, 脓毒症, 小鼠, 生存率

Abstract: AIM: To investigate the dose-related effects of ketamine on cumulative survival in mice models of polymicrobial sepsis induced by cecal ligation and puncture (CLP).METHODS: Mice with CLP were divided randomly into four groups, received ketamine injection intraperitoneally of 0, 3, 6, and 12 mg·100 g^-1, respectively, at 1 and 6 h after CLP.The survival rate was observed in each group.RESULTS: No change in mortality was observed after 72 hours among four groups.Ketamine administration was associated with significant improvement of the survival of mice with CLP (P<0.05), especially in 6 mg·100 g^-1 group (P<0.05).CONCLUSION: Ketamine administration dose-independently delays lethality from sepsis in mice with CLP.

Key words: ketamine, cecal ligation and puncture, sepsis, mice, cumulative survival

中图分类号:

R971.2

刘芬, 陈金和, 李声华, 赵文辉, 艾永循. 氯胺酮对腹腔感染脓毒症小鼠生存率的影响[J]. 中国临床药理学与治疗学, 2004, 9(8): 942-944.

LIU Fen, CHEN Jin-He, LI Sheng-Hua, ZHAO Wen-Hui, AI Yong-Xun. Effects of ketamine on cumulative survival in septic mice induced by cecal ligation and puncture[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2004, 9(8): 942-944.

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