高选择性环氧化酶-2 抑制剂罗非昔布对大鼠关节软骨的影响

中国临床药理学与治疗学 ›› 2004, Vol. 9 ›› Issue (3): 312-317.

高选择性环氧化酶-2 抑制剂罗非昔布对大鼠关节软骨的影响

梁熙, 安洪

重庆医科大学附属第一医院骨科, 重庆400016

收稿日期:2003-08-10 修回日期:2003-11-03 出版日期:2004-03-26 发布日期:2020-11-21
通讯作者: 梁熙, 男, 硕士, 主治医生, 研究方向:骨关节炎, 股骨头缺血坏死。Tel:023-89011018 　E-mail:nazicqcn@hotmail.com

Influence of rofecoxib, a high selective cox-2 inhibitor, on articular cartilage of rats

LIANG Xi, AN Hong

Department of Orthopedic Surgery, the First Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing 400016, China

Received:2003-08-10 Revised:2003-11-03 Online:2004-03-26 Published:2020-11-21

摘要/Abstract

摘要： 目的:考察长期服用高选择性环氧化酶-2(COX-2)抑制剂(罗非昔布)对大鼠关节软骨的影响。方法:切除大鼠一侧跟腱, 造成膝关节骨关节病的早期模型, 非手术侧为正常对照。大鼠随机分成2 组, 一组灌胃给药, 另一组生理盐水灌胃作对照。用药100 d 后, 对关节软骨进行组织学、超微结构观察和组织化学定量分析。结果:罗非昔布长期服用,对骨关节病及非骨关节病的软骨细胞、胶原代谢无不良影响, 在一定程度上可增加软骨蛋白多糖的含量。结论:长期服用罗非昔布对大鼠关节软骨无不良影响。

关键词: 非甾体抗炎药, 关节软骨, 骨关节病, 罗非昔布, 蛋白多糖, 软骨细胞

Abstract: AIM: To observe the influence of rofecoxib, a non-steroidal anti-inf lammatory drug, administrated for a long term on the knee joints cartilage of rats. METHODS: An experimental model of osteoarthritis of left knee in the early stage was induced by cutting achilles tendon in rats, the right knee providing a control.The rats of one group were given rofecoxib orally, and the rats in another group were given saline as a control.After 100 days, the histopathology, ultrastructure, and histochemistry changes on the knee joints cartilage were monitored. RESULTS and CONCLUSION: Rofecoxib, administrated for 100 days, had no harmful influence on chondrocyte and collagen, and could increase proteoglycan of cartilage in some degree in rats.

Key words: non-steroid anti-inflammatory drugs (NSAIDs), cartilage, osteoarthritis, rofecoxib, proteoglycan, chondrocyte

中图分类号:

R965.1

梁熙, 安洪. 高选择性环氧化酶-2 抑制剂罗非昔布对大鼠关节软骨的影响[J]. 中国临床药理学与治疗学, 2004, 9(3): 312-317.

LIANG Xi, AN Hong. Influence of rofecoxib, a high selective cox-2 inhibitor, on articular cartilage of rats[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2004, 9(3): 312-317.

参考文献

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