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中国临床药理学与治疗学 ›› 2024, Vol. 29 ›› Issue (6): 700-706.doi: 10.12092/j.issn.1009-2501.2024.06.012

• 综述与讲座 • 上一篇    下一篇

特纳综合征高血压的研究进展

刘继纯,胡思思,葛涛,谢向荣   

  1. 皖南医学院第一附属医院(弋矶山医院)心内科,芜湖  241000,安徽
  • 收稿日期:2023-12-25 修回日期:2024-03-25 出版日期:2024-06-26 发布日期:2024-05-20
  • 通讯作者: 谢向荣,男,副主任医师,副教授,硕士生导师,研究方向:心血管病学。 E-mail: xiexiangrongwnmc@126.com
  • 作者简介:刘继纯,男,主治医师,讲师,研究方向:心血管病学。 E-mail: liujichun2015@163.com
  • 基金资助:
    安徽省高校科研计划项目(自然科学重点项目)(2022AH051238);安徽省临床重点专科项目(KZSJZ008);皖南医学院校中青年科研基金(WK2023ZQNZ23)

Research progress on association between Turner syndrome and high blood pressure

LIU Jichun, HU Sisi, GE Tao, XIE Xiangrong   

  1. Department of Cardiology, The First Affiliated Hospital of Wannan Medical College, Wuhu 241001, Anhui, China
  • Received:2023-12-25 Revised:2024-03-25 Online:2024-06-26 Published:2024-05-20

摘要:

特纳综合征是临床表型为女性的性染色体病。大部分患者常因生长发育迟缓在儿童或青少年时期被确诊,少部分患者因特纳综合征相关疾病就诊被诊断。特纳综合征的女性在儿童期和青少年时期就可出现高血压,高血压患病率随年龄增长而增加,其发病机制尚不清楚,可能是多因素的,与原发性高血压相似。本综述探讨特纳综合征患者高血压的可能机制、血压管理和治疗建议。

关键词: 高血压, 特纳综合征, 性染色体病

Abstract:

Turner syndrome is a sex chromosome disease with a female clinical phenotype. Most patients are diagnosed in childhood or adolescence because of growth delays, and a small number of patients are diagnosed due to TS-related diseases. Women with Turner syndrome can develop hypertension in childhood and adolescence, and the prevalence of hypertension increases with age. The pathogenesis is unclear and may be multifactorial, similar to essential hypertension. In this review article, we explore possible mechanisms, blood pressure management, and treatment recommendations for hypertension in patients with Turner syndrome.

Key words: high blood pressure, Turner syndrome, sex chromosomal disease

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