戊酸雌二醇片补充治疗对胚胎移植日子宫内膜厚度<7 mm不育患者妊娠结局的影响

中国临床药理学与治疗学 ›› 2011, Vol. 16 ›› Issue (11): 1277-1281.

戊酸雌二醇片补充治疗对胚胎移植日子宫内膜厚度<7 mm不育患者妊娠结局的影响

杨海燕, 赵军招, 林金菊, 余蓉

温州医学院附属第一医院生殖中心,温州 325027,浙江

收稿日期:2011-09-17 修回日期:2011-10-23 出版日期:2011-11-26 发布日期:2011-11-29
通讯作者: 赵军招,女,硕士,主任医师,研究方向:生殖内分泌。Tel: 13606890385 E-mail: Z.joyce@163.com
作者简介:杨海燕,女,硕士,主治医生,研究方向:生殖内分泌。Tel: 13957720491 E-mail: yhypg@sohu.com

Effects of estradiol valerate supplementation on the pregnancy outcome in patients with endometrial thickness less than 7 mm on the day of embryo transfer

YANG Hai-yan, ZHAO Jun-zhao, LIN Jin-ju, YU Rong

Department of Reproductive Medicine, First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, Zhejiang,China

Received:2011-09-17 Revised:2011-10-23 Online:2011-11-26 Published:2011-11-29

摘要/Abstract

摘要： 目的: 探讨戊酸雌二醇片补充治疗对胚胎移植日子宫内膜厚度<7 mm 不育患者妊娠结局的影响。方法: 2009年9月至2010年12月在本中心行体外受精-胚胎移植(IVF-ET)治疗的所有患者在胚胎移植日均再次用阴道超声测定子宫内膜厚度,如子宫内膜厚度<7 mm, 则加用戊酸雌二醇片补充治疗。结果: 胚胎移植日子宫内膜厚度<7 mm 的患者共有60例,共移植了66个周期,148个胚胎。平均内膜厚度(6.21±0.51) mm,平均移植胚胎数(2.14±0.63)个。共有临床妊娠16例,妊娠率为 24.2%,胚胎种植率为 11.5%。自然流产1例,异位妊娠1例。结论: 戊酸雌二醇片补充治疗仍可使胚胎移植日子宫内膜厚度<7 mm 的不育患者仍可获得一定的妊娠率。

关键词: 体外受精-胚胎移植, 子宫内膜, 厚度, 妊娠

Abstract: AIM: To explore the effect of estradiol valerate supplementation on the pregnancy outcome in patients with endometrial thickness less than 7 mm on the day of embryo transfer (ET).METHODS: From November 2009 to December 2010, endometrial thickness and pattern on the day of ET were evaluated again with transvaginal ultrasonogrphy in all patients who received in vitro fertilization and embryo transfer ( IVF-ET) treatment at our reproductive medicine center. The patients were treated with estradiol valerate supplementation if whose endometrial thickness were less than 7 mm.RESULTS: During the study period, a totle of 60 patients with endometrial thickness less than 7 mm underwent 66 transfer cycles, and 148 embryos were transferred. The mean endometrial thickness was(6.21±0.51)mm. The mean number of embryo transfer was (2.14±0.63). Among 66 cycles, there were 16 ongoing pregnancies, the clinical pregnancy rate was 24.2%, the embryo implantation rate was 11.5%. One patient was pontaneous, one patient was ectopic pregnancy.CONCLUSION: Estradiol valerate supplementation treatment can also receive certainly pregnance in patients with endometrial thickness less than 7 mm on the day of embryo transfer.

Key words: IVF-ET, Endometrium, Thickness, Pregnancy

中图分类号:

杨海燕, 赵军招, 林金菊, 余蓉. 戊酸雌二醇片补充治疗对胚胎移植日子宫内膜厚度<7 mm不育患者妊娠结局的影响[J]. 中国临床药理学与治疗学, 2011, 16(11): 1277-1281.

YANG Hai-yan, ZHAO Jun-zhao, LIN Jin-ju, YU Rong. Effects of estradiol valerate supplementation on the pregnancy outcome in patients with endometrial thickness less than 7 mm on the day of embryo transfer[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(11): 1277-1281.

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