Abstract: Objective To investigate the effect about vascular endothelial growth factor（VEGF）、aquapo rin – 4（AQP - 4）on cerebral ischemia-reperfusion injury in rats. Method Adult male SD rats were randomly divided into four groups: sham group; ischemia-reperfusion group; Curcumin - treatment groups: a dose of 100mg / kg; Curcumin - treatment groups: a dose of 300mg / kg.using Plug-line method make focal cerebral ischemia and reperfusion of middle cerebral artery occlusion model of rat. After 48h,Make Neurological deficit scores estimate, Measure Brain water content, Detect blood-brain barrier permeability, Using ELISA to detect the expression of VEGF and AQP - 4, Make HE to observe morphological changes of brain tissue.Result Curcumin can reduce brain water content; Improve the nerve damage symptoms of MCAO rat; Relieve brain morphological changes and BBB permeability; Reduce the expression of VEGF、AQP - 4. In the above changes, the high-dose group showed the most obvious.Conclusion Curcumin can protect cerebral ischemia-reperfusion, This effect may be regulated by Reducing the expression of VEGF and AQP – 4.